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Kinase inhibitory activities of compounds 30–41 against PAK4.
 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Compd. | R3 | PAK4 Ki (μmol/L)a | Compd. | R3 | PAK4 Ki (μmol/L)a | Compd. | R3 | PAK4 Ki (μmol/L)a |
| 30 |  |
0.593 | 34 |  |
0.094 | 38 |  |
0.038 |
| 31 |  |
0.804 | 35 |  |
0.376 | 39 |  |
0.082 |
| 32 |  |
0.243 | 36 |  |
0.455 | 40 |  |
0.044 |
| 33 |  |
0.239 | 37 |  |
0.119 | 41 |  |
0.014 |
PAK4 kinase inhibition was determined using a homogeneous time-resolved fluorescence (HTRF) assay. The Ki values are the average of two independent experiments reported as the mean value.
