Figure 3.

Subgroup analysis of mortality with intensified vs prophylactic anticoagulation, by clinical setting (intensive care unit [ICU] vs hospitalized non-ICU) (A) and by dose of intensified anticoagulation (therapeutic vs intermediate) (B). The single outpatient trial [27] was excluded from the forest plot because of no mortality events. Two other trials were excluded because venous thromboembolic events were not captured as outcomes [30, 31]. Abbreviations: CI, confidence interval; ICU, intensive care unit; REML, restricted maximum likelihood.