Table 1.

PICOT Eligibility Criteria for Study Inclusion

PICOT element		Eligibility criteria
Population		Adults with laboratory-confirmed COVID-19, receiving care in any clinical setting (outpatient or inpatient, including non-ICU and ICU-level care)
Intervention and comparator/exposure		Intermediate-dose prophylactic anticoagulation vs standard low-dose prophylaxisTherapeutic anticoagulation vs standard low-dose prophylaxis
Outcomes	Primary	All-cause mortality at 30 days, death, or dischargea
	Secondary	At 30 days, death, or discharge, rates of:
		1. Venous thromboembolism
		2. Pulmonary embolism
		3. Deep venous thrombosis
		4. Any arterial thrombosis
		5. Any thrombosis
		6. Composite outcome of thrombosis or death
		7. Days requiring organ support
		8. Any requirement for respiratory support (IMV or ECMO)
		9. Major bleeding
		10. Clinically relevant nonmajor bleeding
		11. Major or clinically relevant nonmajor bleeding
		12. Any bleeding

Abbreviations: COVID-19, coronavirus disease 2019; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; IMV, invasive mechanical ventilation; PICOT, population, intervention, comparator, outcomes and timing criteria.

^aStudy deviations from these predefined timepoints have been described in the analysis.