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. 2022 Jun 16;118(15):3085–3096. doi: 10.1093/cvr/cvac097

Figure 1.

Figure 1

Detection of the spike glycoprotein in lung pericytes and decreased CD144 expression in COVID-19 patients. (A) Immunofluorescence imaging of NG2+, spike glycoprotein, and ICAM-1 in formalin-fixed and paraffin-embedded lung from a patient who died from COVID-19 and control COVID-19− (Control) lung sections. (B) High magnification of immunofluorescence imaging of NG2+ and spike glycoprotein in lung section. (C) Quantification of ICAM-1 expression using ImageJ in lung autopsies from two patients who died from non-respiratory-associated diseases, four COVID-19 patients without thrombosis and four patients with detectable thrombosis (3–6 areas per slide). (D) Representative immunofluorescence imaging of CD144 (VE-cadherin) in lung sections. (E) Quantification of CD144 levels using ImageJ. One-way ANOVA with multiple comparisons was performed for each statistical test with significance at (*** P = <0.001).