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. 2022 Jun 8;13:904849. doi: 10.3389/fphar.2022.904849

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Copyright © 2022 Wu, Zhu, Li, Xu, Chang, Du, Cui, Zhang, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CCL suppresses the expression of proinflammatory genes in the light-exposed retinas. Total RNA was isolated from the retinas collected from the indicated experimental groups 6 and 24 h after light exposure. Real-time qPCR analyses were performed to examine the expression of Ccl2 (A), Il1b (B), Il6 (C), and Tnf (D) in the retina. Relative fold change was normalized against that from Normal control. The data were expressed as the mean ± SD (n = 5-6 per group). ^## Compared to Normal control, p < 0.01; ^### Compared to Normal control, p < 0.001; * compared to Light_vehicle, p < 0.05; ** compared to Light_vehicle, p < 0.01; *** compared to Light_vehicle, p < 0.001.