. 2022 Jun 8;12:854973. doi: 10.3389/fonc.2022.854973

Table 3.

Mouse models of epigenetic regulators.

Genemutation	Year	Expression	Mechanism	Phenotype	References
Dnmt3a (KO)	2011	Inducible	Mx1-Cre	Enhanced self-renewal	(107)
	2015	Inducible	Mx1-Cre	MDS, AML, ALL	(101)
	2015	Inducible	Mx1-Cre	MDS, AML, MDS/MPN	(108)
Dnmt3a^R882	2016	Inducible	Mx1-Cre	HSPC expansion, myeloid bias, AML when combined with FLT3+Npm1c	(109)
Dnmt3a^R882	2019	Inducible	Mx1-Cre	AML on serial transplant co-expressed with Npm1c	(110)
Dnmt3a (KO) + Flt3	2017	Inducible	Mx1-Cre	ALL, AML	(94)
Dnmt3a (KO) + Flt3		Inducible	Retrovirus
Dnmt3a (KO) + Tet2	2016	Inducible	Mx1-Cre	ALL, AML	(111)
Dnmt3a (KO) + Tet2		Constitutive
Dnmt3a (KO) + Idh2	2020	Inducible	Mx1-Cre	AML	(112)
Dnmt3a (KO) + Idh2		Inducible	Retrovirus
Tet2 (KO)	2011	Inducible	Mx1-Cre	CMML-like	(113, 114)
	2011	Constitutive		Increased BM cellularity and HSPC expansion	(115)
	2011	Constitutive		CMML, MPN, MDS (low penetrance)	(116)
	2012	Constitutive		Mild myeloproliferation	(117)
Tet2 (KO) + NRAS	2018	Inducible	Mx1-Cre	CMML	(118)
Tet2 (KO) + NRAS		Inducible	Mx1-Cre
Tet2 (KO) + KIT	2018	Constitutive		MPN	(119)
Tet2 (KO) + KIT		Inducible	Mx1-Cre
Asxl1 (KO)	2013	Inducible	Mx1- and Vav- Cre	MDS	(120)
Asxl1 (KO)	2014	Constitutive		MDS, some CMML	(121)
Asxl1 (mut)	2018	Inducible	Vav-Cre	Mild anemia	(122)
Asxl1 (mut)	2021	Constitutive		Mild splenomegaly	(123)
Smc3	2015	Inducible	Mx1-Cre	None (shortened latency of AML when added to Flt3-ITD)	(124)
Smc1a	2015	Inducible	rtTAs	MPN-like	(125)
Bcor	2017	Inducible	CreER	T-ALL	(126)
	2019	Inducible	CreER	AML if combined with Kras^G12D	(127)
	2021	Inducible	Mx1-Cre	(erythroid) AML	(128)

AML, acute myeloid leukemia; BM, bone marrow; CMML, chronic myelomonocytic leukemia; HSPC, hematopoietic stem/progenitor cell; ITD, internal tandem duplication; KO, knock-out; MDS, myelodysplastic syndrome; MPD, myeloproliferative disease; MPN, myeloproliferative neoplasm; PTD, partial tandem duplication; T-ALL, T-acute lymphoblastic leukemia.