Table 4.
Mouse models available for patient-derived xenografts of AML.
| Mouse Strain | Common Abbreviation | Immune system | Cytokines expressed | Engraftment of AML | References | ||
|---|---|---|---|---|---|---|---|
| High-Risk | Intermediate Risk | FavorableRisk | |||||
| nude athymic | nude | T-cell deficient | – | – | – | – | (165–167) |
| C.B-17 SCID | SCID | no functional T- and B-cells | – | + | – | – | (168–171) |
| NOD/LtSz-scid/scid | NOD/SCID | T- and B-cell deficient, reduced NK and macrophage activity | – | ++ | – | – | (172–175) |
| NOD-scid Il2rγnull | NSG | no functional T-, B- and NK cells | – | +++ | ++ | + | (176) |
| NSG–SGM3 | NSGS | no functional T-, B- and NK cells | hIL-3, hGM-CSF, hCSF | ++++ | ++++ | ++ | (177, 178) |
| MISTRG | – | no functional T-, B- and NK cells | hM-CSF, hIL-3, hGM-CSF, hTPO | ++++ | ++++ | +++ | (179–181) |