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. 2022 Jun 8;12:816504. doi: 10.3389/fonc.2022.816504

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Copyright © 2022 Kalyanaraman, Cheng and Hardy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactate exchange between the glycolytic tumor cells present in the hydrophobic core and the oxidative tumor cells. Lactate transported out of the glycolytic cells is taken up by the oxidative cells and used for energy production. Figure licensed under CC BY, copyright ^© 2019 de la Cruz-López, Castro-Muñoz, Reyes-Hernández, García-Carrancá and Manzo-Merino. Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches. Front Oncol. 2019 Nov 1;9:1143.