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. 2022 Jun 8;12:816504. doi: 10.3389/fonc.2022.816504

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Copyright © 2022 Kalyanaraman, Cheng and Hardy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mitochondrial uptake of TPP⁺-containing drugs and natural products into cancer cells due to enhanced hyperpolarization. The top portion of this figure is reprinted (adapted) with permission from Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev. 2017 Aug 9;117(15):10043-10120. Copyright 2017 American Chemical Society. The bottom portion of this figure is adapted from Smith RA, Porteous CM, Gane AM, Murphy MP. Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5407-12. Copyright 2003 National Academy of Sciences.