TABLE 2.

Pharmacokinetic parameters of IMP after intravenous administration of IMP (45 mg/kg) with or without JBP485 (90 mg/kg) in rats.

Parameter	Unit	IMP	IMP + JBP485
C0	μg/ml	137.7 ± 6.1	279.3 ± 6.3**
AUC0-∞	μg/ml·min	890.8 ± 16.8	2,267.7 ± 309.6*
t1/2β	h	1.2 ± 0.4	2.3 ± 0.1*
CLp	ml/min/kg	50.5 ± 1.0	20.1 ± 2.6**
CLR	ml/min/kg	34.0 ± 0.6	5.0 ± 0.6**

Data are expressed as the mean ± SD. ∗p < 0.05 and ∗∗p < 0.01 compared with IMP group (n = 3).