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Km and Vmax values of IMP with or without JBP485 in hOAT1-HEK293 cells and hOAT3-HEK293 cells.
| Group | hOAT1-HEK293 cells | hOAT3-HEK293 cells | ||
|---|---|---|---|---|
| Km | Vmax | Km | Vmax | |
| IMP | 0.564 ± 0.048 | 0.300 ± 0.027 | 0.581 ± 0.064 | 0.450 ± 0.038 |
| IMP + JBP485 | 0.878 ± 0.024* | 0.285 ± 0.021 | 0.994 ± 0.024* | 0.438 ± 0.021 |
Data are expressed as the mean ± SD. ∗ p < 0.05 compared with IMP group (n = 3).
