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. 2022 Jun 8;13:860598. doi: 10.3389/fphar.2022.860598

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Copyright © 2022 Khosravi, Sharifi, Tavakkoli, Molaakbari, Bahraminegad, Salarkia, Seyedi, Keyhani, Salari, Sharifi, Bamorovat, Afgar and Dabiri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amphotericin B and AmBisome affect the blood vessel system. (I) Control embryo with typical blood vessel system. (II and III) Amp B 1x and 2x, respectively. The blood vessel system is disrupted. (IV and V) AmBisome 1X and 2X, respectively. A smaller decrease in vascular density was exhibited compared to Amp B.