TABLE 1.

HLA associations with SSc

	SSc vs. control
	Meta-Analysis cohort						Cohort 1						Cohort 2
HLA allele	SSc prop.(Count)		CO prop.(Count)		OR	p	SSc prop.(Count)		CO prop.(Count)		OR	p	SSc prop.(Count)		CO prop.(Count)		OR	p
DRB1*11:04	0.119	(174/1465)	0.035	(459/13273)	2.81	2.3x10−25	0.099	(50/503)	0.035	(230/6632)	2.36	6.4x10−7	0.129	(124/962)	0.034	(229/6641)	3.08	1.3x10−19
DRB1*07:01	0.152	(223/1465)	0.257	(3406/13273)	0.52	1.5 x10−17	0.157	(79/503)	0.262	(1737/6632)	0.52	2.5x10−7	0.150	(144/962)	0.251	(1669/6641)	0.53	4.4x10−11
DQA1*02:01	0.153	(224/1465)	0.256	(3397/13273)	0.53	3.5 x10−17	0.159	(80/503)	0.261	(1733/6632)	0.53	4.8x10−7	0.150	(144/962)	0.251	(1664/6641)	0.53	5.4x10−11
DQB1*02:02	0.102	(149/1465)	0.186	(2468/13273)	0.49	1.7 x10−15	0.103	(52/503)	0.193	(1282/6632)	0.47	5.9x10−7	0.101	(97/962)	0.179	(1186/6641)	0.51	2.4x10−9
DRB4*01:01	0.111	(162/1465)	0.188	(2491/13273)	0.54	9.3 x10−13	0.109	(55/503)	0.194	(1289/6632)	0.50	2.6x10−6	0.111	(107/962)	0.181	(1202/6641)	0.57	2.9x10−7
DPB1*13:01	0.076	(111/1465)	0.033	(444/13273)	2.20	1.8 x10−12	0.068	(34/503)	0.035	(231/6632)	1.85	0.001	0.080	(77/962)	0.032	(213/6641)	2.50	7.5x10−11
B*44:03	0.050	(73/1465)	0.105	(1397/13273)	0.45	1.8 x10−10	0.066	(33/503)	0.110	(728/6632)	0.57	0.002	0.042	(40/962)	0.101	(669/6641)	0.40	4.9x10−8
C*16:01	0.038	(55/1465)	0.082	(1090/13273)	0.44	6.2 x10−9	0.050	(25/503)	0.086	(573/6632)	0.55	0.004	0.031	(30/962)	0.078	(517/6641)	0.39	9.1x10−7
DQA1*05:01	0.508	(744/1465)	0.421	(5583/13273)	1.34	1.7 x10−7	0.509	(256/503)	0.414	(2747/6632)	1.40	0.0003	0.507	(488/962)	0.427	(2836/6641)	1.29	0.0003

CO = control, OR = odds ratio, p = p-value.