TABLE 4.
KIR interactions with HLA class I subtypes and alleles.
| — | Metanalysis | Cohort 1 | Cohort 2 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HLA | KIR | SSc prop.(Count) | CO prop.(Count) | OR | p | pint | SSc prop.(Count) | CO prop.(Count) | OR | p | pint | SSc Prop.(Count) | CO prop.(Count) | OR | p | pint | ||||||
| Bw4 | 3DL1+ | 0.677 | (947/1399) | 0.722 | (9121/12639) | 0.77 | 2x10−5 | 0.02 | 0.683 | (332/486) | 0.72 | (4542/6305) | 0.81 | 0.03 | 0.06 | 0.674 | (615/913) | 0.723 | (4579/6334) | 0.75 | 0.0002 | 0.15 |
| 3DL1- | 0.833 | (55/66) | 0.729 | (462/634) | 1.62 | 0.17 | 0.941 | (16/17) | 0.722 | (236/327) | 5.21 | 0.12 | 0.796 | (39/49) | 0.736 | (226/307) | 1.27 | 0.54 | ||||
| C1 | 2DL3+ | 0.861 | (1139/1323) | 0.871 | (10537/12097) | 0.99 | 0.88 | 0.03 | 0.889 | (399/449) | 0.87 | (5270/6058) | 1.29 | 0.10 | 0.60 | 0.847 | (740/874) | 0.872 | (5267/6039) | 0.86 | 0.15 | 0.02 |
| 2DL3-/L2++/S2++ | 0.93 | (132/142) | 0.867 | (1020/1176) | 2.14 | 0.03 | 0.926 | (50/54) | 0.88 | (505/574) | 1.96 | 0.22 | 0.932 | (82/88) | 0.855 | (515/602) | 2.63 | 0.03 | ||||
| Metanalysis | Cohort 1 | Cohort 2 | ||||||||||||||||||||
| KIR | HLA Allele | SSc prop.(Count) | CO prop.(Count) | OR | p | p pnt | SSc prop.(Count) | CO prop.(Count) | OR | p | p int | SSc prop.(Count) | CO prop.(Count) | OR | p | p int | ||||||
| 2DL3 | C*16+ (C1/C2) | 0.797 | (59/74) | 0.902 | (1044/1157) | 0.44 | 0.009 | 0.02 | 0.828 | (24/29) | 0.902 | (543/602) | 0.49 | 0.18 | 0.43 | 0.778 | (35/45) | 0.903 | (501/555) | 0.38 | 0.02 | 0.01 |
| C*16- (C1/C2) | 0.909 | (1264/1391) | 0.912 | (11053/12116) | 1.01 | 0.93 | 0.897 | (425/474) | 0.915 | (5515/6030) | 0.85 | 0.30 | 0.915 | (839/917) | 0.910 | (5538/6086) | 1.12 | 0.37 | ||||
Statistical interactions between biologically interacting KIR and HLA subgroups or alleles reaching statistical significance (p < 0.05) in the meta-analysis cohort. + = positive, − = negative, ++ = homozygous, OR = odds ratio, CO = control, p = p-value, pint = KIRxHLA interaction term p-value.