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. 2022 Jun 8;10:887393. doi: 10.3389/fcell.2022.887393

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Copyright © 2022 Alhashem, Camargo-Sosa, Kelsh and Linker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Leaders TNC divide asymmetrically while followers divide symmetrically (A,B) Confocal images of Sox10:mG (A) and 3D rendering (B) of leader asymmetric division into distal and proximal daughters. L: Leader, LD: Leader Distal, LP: Leader Proximal; white arrow indicates direction of migration and yellow arrowhead points to the dividing cell (C,D) Confocal images of Sox10:mG (C) and 3D rendering (D) of follower symmetric division. F: Follower, Fa and Fb Follower’s daughters (E) Quantification of cell area of leaders’ and followers’ daughters quantified immediately after division (n = 25 for leaders and n = 44 for followers; Unpaired t test, p = 0.0001 for LD vs. LP and p = 0.5852 for Fa vs. Fb) (F) Quantification of cell volume of leaders, followers and their daughters after division (n = 10 divisions for leaders and n = 10 divisions for followers; Brown-Forsythe and Welch ANOVA tests, p < 0.0001 for L vs. LD and LP, p < 0.0001 for LD vs. LP, p = 0.0012 for F vs. Fa and Fb, p > 0.9999 for Fa vs. Fb) (G) Cell volume over time of a representative leader before and after division (H) Quantification of speed of movement of leaders’ and followers’ daughters (n = 25 for leaders and n = 44 for followers; Unpaired t test, p = 0.0072 for LD vs. LP, p = 0.8690 for Fa vs. Fb) (I) Directionality ratio of leaders’ daughters (n = 25 divisions; Simple linear regression, p < 0.0001 for LD vs. LP) (J) Directionality correlation of leaders’ and followers’ daughters (n = 25 for leaders and n = 44 for followers; Welch’s t test, p = 0.0004 for LD vs. LP, p = 0.2798 for Fa vs. Fb).