TABLE 2.

Adalimumab and infliximab (TNFα) model parameters.

Parameter	Value	Unit	Reference
Drug Valency	1	-	Lim et al., 2018; Tran et al., 2017
Adalimumab Dosing Interval	2	weeks	Adalimumab, 2021
Infliximab Dosing Interval	8	weeks	Infliximab, 2013
Adalimumab Half-Life	20	days	Adalimumab, 2021; Weisman et al., 2003; Ternant et al., 2015
Infliximab Half-Life	14	days	Hemperly and Niels Vande, 2018
Adalimumab Molecular Weight	148,000	Daltons	Adalimumab, 2021
Infliximab Molecular Weight	149,100	Daltons	Infliximab, 2013
Adalimumab KD	8.6	pM	Kaymakcalan et al., 2009
Infliximab KD	4.2	pM	Kaymakcalan et al., 2009
TNF Concentration	5.73e-5	nM	Takeuchi et al., 2011
TNF Half-Life	30	min	Moritz et al., 1989
TNF:TNFR KD	19	pM	Grell et al., 1998
TNFR Concentration	0.23	nM	Bottom up calculation
TNFR receptor half-life	9	hr	Higuchi 1994
Volume	5	L	Typical volume of distribution for mAb
Body weight	70	kg	Typical body weight for man