TABLE 3.

EGFR and c-met target parameters.

Parameter	Value	Unit	Reference
EGFR expression central	4.57E-02	nmoles	Bottom up calculation
EGFR expression peripheral	1.47E+01	nmoles	Bottom up calculation
EGFR receptor half-life	5	hours	Sigismund et al., 2008
Met expression central	3.20E-02	nmoles	Bottom up calculation
Met expression peripheral	5.86E+00	nmoles	Bottom up calculation
Met receptor half-life	4	hours	Li et al., 2008; Da Silva et al., 2020
soluble Met concentration	5.9	nM	Rosen et al., 2017; Gao et al., 2016
soluble Met half-life	48	hours	Estimate based on protein molecular weight; Li et al., 2017
Central compartment volume	3	L	Plasma volume; Shah and Betts, 2012
Peripheral Compartment volume	13	L	Interstitial volume of peripheral tissues; Shah and Betts, 2012
Body weight	70	kg	Typical body weight for man