Table 1.

Clinicopathological characteristics of the global cohort [retrospective cases (n = 436) and patient index cases (n = 3)].

Characteristic	N = 439
Age, median (range) (ys)	62 (18.0–88.0)
Histological subtype  Typical carcinoid  Atypical carcinoid  LCNEC   Index cases   Retrospective cases  SCLC  Mixed histology	91 (20.7) 69 (15.8) 63 (14.6) 3 61 206 (46.9) 9 (2.0)
Sex, n (%)  Women  Men  Unknown	142 (32.3) 157 (35.8) 140 (31.9)
TNM stage, n (%)  I  II  IIIA  IIIB  IV   Index cases   Retrospective cases  Unknown	104 (23.7) 29 (6.6) 31 (7.1) 4 (0.9) 14 (3.2) 3 11 257 (58.5)

LCNEC, large cell neuroendocrine carcinoma; n, number of samples; SCLC, small cell lung cancer; ys, years. TNM staging was performed at diagnosis.

All 3 index cases were LCNEC with an initial TNM stage IV.