Table 2.
Clinicopathological data and ALK results for all ALK IHC-positive (1+ to 3+) cases.
| No. | Tumor Type | IHC score | FISH | NGS | TNM/Stage**** |
|---|---|---|---|---|---|
| 1 * | LCNEC | 3 | Positive | EML4-ALK | cT1 cN3 cM1c, IVB |
| 2 ** | LCNEC | 3 | NA | EML4-ALK | cT2 cN1 pM1c, IVB |
| 3 *** | LCNEC | 3 | Positive | EML4-ALK | cT3 cN3 cM1a, IVA |
| 4 | AC | 3 | Positive | STRN-ALK | pT2 pN2 cM0, IIIA |
| 5 | LCNEC | 2 | Positive | NA | pT1 pN3, cM0, IIIB |
| 6 | AC | 1 | Positive | NA | pT2 pN2, cM0, IIIA |
| 7 | LCNEC | 3 | Negative | No fusion | - |
| 8 | SCLC | 3 | Negative | No fusion | - |
| 9 | SCLC | 3 | NA | No fusion | - |
| 10 | SCLC | 3 | NA | NA | – |
| 11 | SCLC | 3 | Negative | NA | - |
| 12 | AC | 3 | Negative | No fusion | - |
| 13 | AC | 3 | Negative | No fusion | - |
| 14 | AC | 3 | Negative | NA | - |
| 15 | AC | 3 | NA | NA | - |
| 16 | TC | 3 | NA | NA | - |
| 17 | TC | 3 | Negative | No fusion | - |
| 18 | SCLC | 2 | Negative | No fusion | - |
| 19 | AC | 2 | Negative | No fusion | - |
| 20 | AC | 2 | Negative | No fusion | - |
| 21 | TC | 2 | Negative | No fusion | - |
| 22 | TC | 2 | Negative | No fusion | - |
| 23 | TC | 2 | Negative | NA | - |
| 24 | LCNEC | 1 | Negative | NA | - |
| 25 | SCLC | 1 | NA | NA | - |
| 26 | SCLC | 1 | NA | NA | - |
| 27 | SCLC | 1 | Negative | NA | - |
| 28 | SCLC | 1 | Negative | AN | - |
| 29 | AC | 1 | Negative | NA | - |
| 30 | AC | 1 | NA | NA | - |
| 31 | AC | 1 | Negative | NA | - |
| 32 | AC | 1 | Negative | NA | - |
| 33 | AC | 1 | Negative | NA | – |
| 34 | TC | 1 | Negative | NA | – |
| 35 | TC | 1 | Negative | NA | – |
| 36 | TC | 1 | Negative | NA | – |
| 37 | TC | 1 | Negative | NA | – |
| 38 | TC | 1 | Negative | NA | – |
AC, atypical carcinoid; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization; LCNEC, large cell neuroendocrine carcinoma; NA, not available; NGS, next-generation sequencing; SCLC, small cell lung cancer; TC, typical carcinoid. *case report 1, **case report 2, ***case report 3, ****TNM stage at diagnosis.
Bold cases: ALK rearrangement positive by FISH or NGS.