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. 2022 Jun 8;12:807264. doi: 10.3389/fonc.2022.807264

Table 1.

Clinicopathological characteristics of patients in the training, testing, and external validation cohorts.

Training set (n=666) Testing set (n=117) ExternalValidation set (n=102)
PCR (%)(n=171) Non-PCR (%)(n=495) P value PCR (%)(n=30) Non-PCR (%)(n=87) P value PCR (%)(n=24) Non-PCR (%)(n=78) P value
Age, mean(SD), y 52.77 ± 12.02 54.71 ± 11.78 0.078 53.90 ± 11.71 55.38 ± 11.47 0.549 54.08 ± 11.01 57.17 ± 10.37 0.182
Sex, No. (%) 0.849 0.376 0.081
Female 55(32.2) 154(31.1) 8(26.7) 32(36.8) 12(50.0) 22(28.2)
Male 116(67.8) 341(68.9) 22(73.3) 55(63.2) 12(50.0) 56(71.8)
Clinical T stage
cT2 10(5.9) 16(3.2) 0.124 2(6.7) 2(2.3) 0.271 1(4.2) 0(0.0) 0.235
cT3 113(66.1) 323(65.3) 0.926 20(66.7) 55(63.2) 0.827 9(37.5) 24(30.8) 0.612
cT4 48(28.0) 156(31.5) 0.442 8(26.6) 30(34.5) 0.503 14(58.3) 54(69.2) 0.333
Clinical N stage
cN0 34(19.9) 76(15.4) 0.189 5(16.7) 13(14.9) 0.777 0(0.0) 18(23.1) 0.006
cN1 86(50.3) 249(50.3) 1 13(43.3) 40(46.0) 0.834 17(70.8) 43(55.1) 0.236
cN2 51(29.8) 170(34.3) 0.301 12(40.0) 34(39.1) 1 7(29.2) 17(21.8) 0.582
TNM stage
Stage II 35(20.5) 76(15.3) 0.167 5(16.6) 13(14.9) 0.777 0(0.0) 18(23.1) 0.006
Stage III 136(79.5) 419(84.7) 0.124 25(83.4) 74(85.1) 0.777 24(100.0) 60(76.9) 0.006
Histological grade
1 22(12.9) 55(11.1) 0.579 3(10.0) 16(18.4) 0.394 1(4.2) 0(0) 0.235
2 125(73.1) 382(77.2) 0.299 22(73.3) 65(74.7) 1 23(95.8) 71(91.0) 0.677
3 24(14.0) 58(11.7) 0.421 5(16.7) 6(6.9) 0.147 0(0) 7(9.0) 0.194
Patch No. 102,728 18475 46599