Table 3.
Univariate and multivariate logistic regression analyses.
| (a) Univariate logistic regression | Testing Set | External Validation Set | ||
|---|---|---|---|---|
| P value | Exp (B) (95% CI) | P value | Exp (B) (95% CI) | |
| Sex | 0.316 | 1.6 (0.638, 4.011) | 0.051 | 0.393 (0.153, 1.006) |
| Age | 0.051 | 2.679 (0.995, 7.212) | 0.042 | 2.768 (1.039, 7.376) |
| TNM stage | 0.822 | 1.138 (0.369, 3.513) | 0.998 | 0 (0, -) |
| CEA | 0.033 | 2.796 (1.087, 7.197) | 0.029 | 3.667 (1.145, 11.74) |
| CA-199 | 0.087 | 2.128 (0.896, 5.055) | 0.054 | 2.505 (0.985, 6.37) |
| CRP | 0.198 | 2.348 (0.639, 8.621) | – | |
| LDH | 0.999 | 5.80e8 (0, -) | 0.207 | 2.4 (0.617, 9.339) |
| Lymphocytes | 0.24 | 2.186 (0.593, 8.062) | 0.133 | 2.2 (0.788, 6.146) |
| Neutrophils | 0.414 | 1.524 (0.555, 4.186) | 0.097 | 2.508 (0.846, 7.436) |
| NLR | 0.142 | 3.155 (0.681, 14.623) | 0.04 | 3.045 (1.054, 8.804) |
| Patch-indi | 0.06 | 2.248 (0.967, 5.224) | 0.219 | 1.786 (0.709, 4.5) |
| Patch-comb | 0.053 | 2.548 (0.989, 6.564) | 0.023 | 3.143 (1.171, 8.437) |
| DeepPCR | 0.0001 | 6.125 (2.462, 15.239) | 0.0001 | 7 (2.575, 19.028) |
| (b) Multivariate logistic regression | Test Cohort | External Validation Cohort | ||
| Sig. | Exp (B) (95% CI) | Sig. | Exp (B) (95% CI) | |
| Sex | 0.143 | 2.45 (0.739, 8.124) | 0.011 | 0.122 (0.024, 0.621) |
| Age | 0.489 | 1.576 (0.434, 5.72) | 0.705 | 1.346 (0.289, 6.261) |
| TNM stage | 0.965 | 1.034 (0.233, 4.582) | 0.998 | 0 (0, -) |
| CEA | 0.101 | 2.718 (0.823, 8.973) | 0.189 | 3.211 (0.564, 18.284) |
| CA-199 | 0.124 | 2.413 (0.785, 7.415) | 0.059 | 4.137 (0.945, 18.108) |
| CRP | 0.104 | 4.607 (0.732, 29.003) | ||
| LDH | 0.999 | 2.6e8 (0, -) | 0.118 | 7.334 (0.604, 89.051) |
| Lymphocytes | 0.128 | 3.412 (0.704, 16.539) | 0.203 | 3.418 (0.514, 22.723) |
| Neutrophils | 0.979 | 0.981 (0.239, 4.023) | 0.874 | 0.846 (0.107, 6.699) |
| NLR | 0.138 | 4.242 (0.628, 28.678) | 0.05 | 8.854 (0.995, 78.749) |
| Patch-indi | 0.346 | 1.657 (0.58, 4.732) | 0.831 | 0.855 (0.204, 3.591) |
| Patch-comb | 0.8 | 0.819 (0.175, 3.842) | 0.642 | 1.453 (0.301, 7.023) |
| DeepPCR | 0.008 | 6.879 (1.646, 28.743) | 0.004 | 10.461 (2.138, 51.186) |
(a) Univariate logistic regression analysis of the testing set and external validation set. (b) Multivariate logistic regression analysis of the testing set and external validation set. The covariates were sex, age, TNM stage, CEA, CA19-9, CRP, LDH, lymphocytes, neutrophils, neutrophil-to-lymphocyte ratio (NLR), patch-based individual (patch-indi) model, patch-based combined (patch-comb) model, and DeepPCR model.