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Molecules' number of the five simulated LNP systems.
| Parameter | mRNA | MC3-3:1 | MC3-6:1 | SM102-3:1 | SM102-6:1 |
|---|---|---|---|---|---|
| N/P ratioa | NA | 3:1 | 6:1 | 3:1 | 6:1 |
| mRNAb | 1 | 1 | 1 | 1 | 1 |
| MC3 | 0 | 96 | 192 | 0 | 0 |
| SM-102 | 0 | 0 | 0 | 96 | 192 |
| Cholesterol | 0 | 74 | 148 | 74 | 148 |
| DSPC | 0 | 19 | 38 | 19 | 38 |
| PEG2000-DMG | 0 | 3 | 6 | 3 | 6 |
| Na+ | 31 | 0 | 0 | 0 | 0 |
| Cl‒ | 0 | 65 | 162 | 65 | 161 |
| Water | 6190 | 69,747 | 98,183 | 68,936 | 97,877 |
The number ratio between the nitrogen groups of ionizable lipids to phosphate groups of mRNA sequence.
The mRNA consists of 32-mer of poly (A).
