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Encapsulation efficiency and particle size of LNPs.
| Formulationa | MC3-3:1 | MC3-6:1 | SM102-3:1 | SM102-6:1 |
|---|---|---|---|---|
| Encapsulation efficiency | 89.5% | 91.3% | 89.6% | 91.2% |
| Particle size (nm) | 97.8 | 101.0 | 101.2 | 106.3 |
LNP was formulated from ionizable lipid, DSPC, cholesterol, and PEG-lipid at a molar ratio of 50:10:38.5:1.5. The N/P ratio was 6:1 or 3:1.
