Table 4.
Summary of Host and Microbial Features of Psoriasis Subgroups
| Characteristic | PSO2 and PSO3 Common Features | PSO2-Specific Features | PSO3-Specific Features |
|---|---|---|---|
| Metagenomics (stool) |
Turicibacter spp. ↓ Phascolarctobacterium succinatutens ↓ |
Bacteroides xylanisolvans ↑ Prevetella copri ↓ Streptococcus thermophilus ↓ Coprococcus sp ART55 1 arginine and polyamine biosynthesis ↓ pyridoxal 5-phosphate biosynthesis ↑ |
Megamonas spp. ↑ Ruminococcaceae bacterium D16 ↓ Lachnospiraceae bacterium 1 1 57FAA ↓ |
| Transcriptomics (sigmoid colon) | NA | SULT1C2 and SULT1C3 ↓ FOHL1 ↓ PDE9A ↑ |
FOHL1 ↑ UCP2 ↑ HTR3A ↑ |
| Gut immune cell population (sigmoid colon digital cytometry) | NA | NA | CD8 T cells ↑ Activated CD4 T cells ↓ NK cells ↓ |
| Immune population (PBMC flow cytometry) | NA | Reduced activated memory CD4 and CD8 | NA |
| Cytokine production (PBMC flow cytometry) | NA | Higher IL-22 production in CD8 and higher TNF-α production in γδ T cells | NA |
Abbreviation: NA, not applicable.