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. 2022 Mar 10;2(3):100115. doi: 10.1016/j.xjidi.2022.100115

Supplementary Table S11.

List of Significant Associations in Host Microbial Multiomics Network

From To Cor P-Value Padj Greedy Membership
Significant associations in health-associated network
s__Catenibacterium_mitsuokai CD8_TNFa_only 0.80837 0.000118 0.047311 1
PWY4FS-7: phosphatidylglycerol biosynthesis I (plastidic) Teff_IFNg_Only 0.643956 0.00019 0.095866
PWY4FS-8: phosphatidylglycerol biosynthesis II (non-plastidic) Teff_IFNg_Only 0.643956 0.00019 0.095866
PWY4FS-7: phosphatidylglycerol biosynthesis I (plastidic) Teff_TNFa_INFg 0.621978 1.49E–06 0.003106
PWY4FS-8: phosphatidylglycerol biosynthesis II (non-plastidic) Teff_TNFa_INFg 0.621978 1.49E–06 0.003106
CD8_TNFa_only IL1R2 ‒0.68647 2.35E–06 0.006511
s__Catenibacterium_mitsuokai NOS2 0.805281 0.000223 0.096093
Teff_TNFa_INFg NOS2 0.775824 0.000257 0.091006
CD8_TNFa_only ST6GAL2 ‒0.64466 3.23E–05 0.030873
s__Catenibacterium_mitsuokai ST6GAL2 ‒0.66447 4.78E–06 0.005155
PHOSLIPSYN-PWY: superpathway of phospholipid biosynthesis I (bacteria) CD8_IFNg_only 0.767033 0.000162 0.092121 2
Treg_INFg_only CCDC144A 0.749451 0.000105 0.062263
Treg_INFg_only RP11-219A15.1 0.796066 2.5E–05 0.02777
CD8_IFNg_only RP11-336A10.5 0.818482 2.1E–05 0.02777
CD8_IL22_only RP11-336A10.5 0.752476 0.000181 0.080494
Treg_INFg_only RP11-336A10.5 0.673268 0.000104 0.062263
Treg_TNFa_IFNg RP11-336A10.5 0.790289 0.000219 0.088193
Treg_INFg_only USP32P1 0.783672 0.000112 0.06403
PWY-6125: superpathway of guanosine nucleotides de novo biosynthesis II activated.memory.Teff 0.686469 0.000357 0.021066 3
PWY-7184: pyrimidine deoxyribonucleotides de novo biosynthesis I activated.memory.Teff 0.638767 0.000445 0.025005
PWY-7197: pyrimidine deoxyribonucleotide phosphorylation activated.memory.Teff 0.613862 0.001624 0.073648
s__Escherichia_coli activated.memory.Teff 0.60066 1.89E–05 0.003131
FUC-RHAMCAT-PWY: super pathway of fucose and rhamnose degradation Active.Teff 0.786207 0.001056 0.051489
PWY-6125: super pathway of guanosine nucleotides de novo biosynthesis II Active.Teff 0.63631 0.001602 0.073212
PWY-6628: superpathway of L-phenylalanine biosynthesis Active.Teff 0.728019 7.38E–06 0.0016
s__Escherichia_coli Active.Teff 0.660784 8.59E–06 0.001669
UniRef90_K6B179: NO_NAME Active.Teff 0.604715 1.58E–06 0.041485
s__Eubacterium_ventriosum IGLV8-61 ‒0.73511 0.000141 0.073261 4
s__Ruminococcus_obeum IGLV8-61 ‒0.6 0.000147 0.0755
UniRef90_A5ZMH0: NO_NAME IGLV8-61 ‒0.81588 2.75E–06 0.065021
UniRef90_D4LLH7: ATPases involved in chromosome partitioning IGLV8-61 ‒0.76686 3.19E–06 0.070247
UniRef90_R6S2S2: Ketol-acid reductoisomerase IGLV8-61 ‒0.71356 5.13E–06 0.091049
GLYCOLYSIS: glycolysis I (from glucose 6-phosphate) memory.CD8 0.78022 0.000181 0.011891 5
PWY-5484: glycolysis II (from fructose 6-phosphate) memory.CD8 0.789011 0.000203 0.013021
UniRef90_D4M0P1: ADP-ribose pyrophosphatase memory.CD8 0.899252 1.03E–05 0.087323
NONOXIPENT-PWY: pentose phosphate pathway (non-oxidative branch) RP11-716A19.3 0.61012 7.69E–06 0.031569 6
UniRef90_R7JV77: NO_NAME RP11-716A19.3 0.610793 4.62E–06 0.086393
NONOXIPENT-PWY: pentose phosphate pathway (non-oxidative branch) RP4-672N11.1 0.61012 7.69E–06 0.031569
UniRef90_R7JV77: NO_NAME RP4-672N11.1 0.610793 4.62E–06 0.086393
PPGPPMET-PWY: ppGpp biosynthesis activated.memory.CD8 0.601323 0.001952 0.08521 7
PWY-821: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) activated.memory.CD8 0.686806 7.64E–05 0.006382
NONMEVIPP-PWY: methylerythritol phosphate pathway I ADGRG7 0.868132 2.01E–05 0.062622 8
s__Prevotella_copri ADGRG7 0.871288 3.52E–05 0.0262
GLUCUROCAT-PWY: superpathway of β-D-glucuronide and D-glucuronate degradation SULT1C2 ‒0.92527 2.97E–05 0.078414 9
UniRef90_D4K8E3: Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 SULT1C2 ‒0.9083 7.16E–07 0.027384
CD8_Immune.function ZG16 0.732674 0.000189 0.080761 10
CD8_Immune.Pop ZG16 0.767033 3.68E–05 0.065578
UniRef90_C7H1R7: NO_NAME MST1L ‒0.90309 1.41E–06 0.040723 11
UniRef90_C7H1R7: NO_NAME MST1P2 ‒0.89428 3.41E–07 0.020076
s__Eubacterium_hallii AP000350.5 0.91339 9.22E–05 0.05574 12
s__Eubacterium_hallii AP000350.6 0.792502 0.000112 0.062974
UniRef90_D4K1Q8: Predicted integral membrane protein HELLPAR 0.719472 1.51E–06 0.04237 13
UniRef90_E2ZN70: NO_NAME HELLPAR 0.803967 4.87E–06 0.089006
s__Bacteroides_dorei LL22NC03-23C6.12 0.61662 7.52E–05 0.049355 14
s__Bacteroides_dorei RP11-174O3.6 0.604902 9.1E–05 0.055665
UniRef90_G2SYP7: NO_NAME RP11-745A24.3 0.704199 2.9E–06 0.065432 15
UniRef90_G2T527: Filamentation induced by cAMP protein Fic RP11-745A24.3 0.72507 3.86E–06 0.07883
Teff_TNFa_only IGHV6-1 ‒0.80968 2.48E–05 0.02777 16
Teff_TNFa_only REG1A 0.610445 7.99E–05 0.062263
PWY-7219: adenosine ribonucleotides de novo biosynthesis ITGA2 ‒0.91969 2.74E–05 0.076724 17
s__Dorea_formicigenerans Teff_Immune.Pop ‒0.91209 0.000234 0.020021 18
Treg_IL17_IL22 IGLV2-18 ‒0.76005 0.000208 0.086495 19
CD8_TNFa_IFNg TM4SF1 ‒0.65714 0.000312 0.098059 20
UniRef90_R6LGS5: NO_NAME AC131056.3 ‒0.89989 2.79E–06 0.065021 21
ILC3 IGHD 0.748352 7.96E–06 0.018936 22
UniRef90_R5TP61: 50S ribosomal protein L30 IGHV3-33 ‒0.70751 1.16E–06 0.036628 23
UniRef90_R9HTU6: NO_NAME FTMT 0.612826 1.82E–07 0.012321 24
PWY-5177: glutaryl-CoA degradation CDA 0.816282 1.43E–05 0.049172 25
s__Ruminococcus_lactaris EML6 0.76199 4.06E–05 0.029981 26
PWY-7328: superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis IL17F 0.780793 2.95E–05 0.078414 27
UniRef90_D4KCX5: Rhamnulose-1-phosphate aldolase CD177P1 0.963551 2.32E–06 0.056574 28
PWY0-1061: superpathway of L-alanine biosynthesis CD8_IL17_only 0.760754 4.74E–06 0.006165 29
s__Ruminococcus_sp_5_1_39BFAA CD19 0.781079 0.000124 0.066737 30
Significant associations in psoriasis-associated network
1CMET2-PWY: N10-formyl-tetrahydrofolate biosynthesis GAPDHP1 ‒0.6841 9.75E–05 0.064441 1
ARGININE-SYN4-PWY: L-ornithine de novo biosynthesis GAPDHP1 ‒0.7126 2.17E–05 0.023794
PWY-3841: folate transformations II GAPDHP1 ‒0.65402 0.00017 0.092741
PWY-5101: L-isoleucine biosynthesis II GAPDHP1 ‒0.68194 0.000136 0.080946
PWY-6353: purine nucleotides degradation II (aerobic) GAPDHP1 0.663131 0.000167 0.091415
PWY-7282: 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis (yeast) GAPDHP1 ‒0.69345 2.78E–05 0.027634
PWY0-845: super pathway of pyridoxal 5-phosphate biosynthesis and salvage GAPDHP1 ‒0.71761 9.73E–06 0.013577
PYRIDOXSYN-PWY: pyridoxal 5-phosphate biosynthesis I GAPDHP1 ‒0.71319 1.28E–05 0.01645
UniRef90_A7V4G2: NO_NAME GAPDHP1 ‒0.75316 5.57E–06 0.058996
UniRef90_Q5LC85: Elongation factor 4 GAPDHP1 ‒0.75949 1.37E–06 0.02837
UniRef90_Q5LES4: Sulfate adenylyltransferase subunit 2 GAPDHP1 ‒0.78468 1.2E–06 0.027047
ARGININE-SYN4-PWY: L-ornithine de novo biosynthesis MIR222HG 0.677723 0.000185 0.098183
PWY-6703: preQ0 biosynthesis MIR222HG 0.635198 0.000171 0.092877
PWY0-845: super pathway of pyridoxal 5-phosphate biosynthesis and salvage MIR222HG 0.697094 0.000186 0.098528
s__Bacteroides_uniformis MIR222HG 0.718291 8.08E–05 0.030159
PWY-6353: purine nucleotides degradation II (aerobic) MTND1P23 ‒0.73465 9.63E–05 0.06407
s__Bacteroides_uniformis NPIPB15 ‒0.60205 0.000127 0.043035
PWY-6703: preQ0 biosynthesis NUAK2 ‒0.69266 0.000187 0.098672
ARGININE-SYN4-PWY: L-ornithine de novo biosynthesis RN7SKP299 0.705078 0.000141 0.082044
PWY-5101: L-isoleucine biosynthesis II RN7SKP299 0.773598 1.22E–05 0.01603
ARGININE-SYN4-PWY: L-ornithine de novo biosynthesis RP11-16E12.2 ‒0.71602 0.000189 0.098755
UniRef90_R5EN96: NO_NAME AP001627.1 0.718549 7.47E–06 0.070498 2
UniRef90_R5ENA5: NO_NAME AP001627.1 0.705786 5.84E–06 0.060871
UniRef90_R5ENA9: NO_NAME AP001627.1 0.651182 7.75E–06 0.072187
UniRef90_R5ENB7: NO_NAME AP001627.1 0.676065 4.98E–06 0.05694
UniRef90_R5ENC3: NO_NAME AP001627.1 0.695925 6.58E–06 0.065657
UniRef90_R5END3: NO_NAME AP001627.1 0.660024 8.62E–06 0.075666
UniRef90_R5ENY1: NO_NAME AP001627.1 0.678813 5.08E–06 0.057196
UniRef90_R5ENZ3: NO_NAME AP001627.1 0.660032 9.77E–06 0.080475
UniRef90_R5EP09: NO_NAME AP001627.1 0.607497 9.06E–06 0.077542
UniRef90_R5ES58: NO_NAME AP001627.1 0.712702 7.09E–06 0.068494
UniRef90_R5ES70: NO_NAME AP001627.1 0.698935 5.74E–06 0.06032
UniRef90_R5ES82: NO_NAME AP001627.1 0.726586 7.68E–06 0.072187
UniRef90_R5EXU5: NO_NAME AP001627.1 0.665197 7.19E–06 0.069054
UniRef90_R5F071: NO_NAME AP001627.1 0.690192 6.4E–06 0.064816
UniRef90_R5F076: NO_NAME AP001627.1 0.759732 4.82E–06 0.056148
UniRef90_R5F1R6: NO_NAME AP001627.1 0.669014 9.65E–06 0.080053
UniRef90_R5F1S4: NO_NAME AP001627.1 0.698402 5.46E–06 0.058301
UniRef90_R5F1T5: NO_NAME AP001627.1 0.677638 3.89E–06 0.051875
UniRef90_R5VN00: NO_NAME AP001627.1 0.707391 5.26E–06 0.057636
UniRef90_C7H6T5: NO_NAME CXCL1 0.607639 1.68E–07 0.006928 3
UniRef90_C7H6T5: NO_NAME CXCL3 0.62271 3.3E–08 0.002159
UniRef90_G2T376: NO_NAME CXCL3 0.61847 9.73E–10 0.000185
UniRef90_G2T5J9: NO_NAME CXCL3 0.607058 2.91E–08 0.001971
PWY-7196: superpathway of pyrimidine ribonucleosides salvage Teff_IL17_IL22 0.703267 0.00045 0.078835 4
PWY-7196: superpathway of pyrimidine ribonucleosides salvage Teff_IL17_only 0.62053 0.000127 0.064567
PPGPPMET-PWY: ppGpp biosynthesis Treg_IL17_only 0.607528 0.000525 0.085532
PWY-7196: superpathway of pyrimidine ribonucleosides salvage Treg_IL17_only 0.630174 0.000704 0.095585
COLANSYN-PWY: colanic acid building blocks biosynthesis IGHV3-30 ‒0.6278 0.000129 0.077505 5
PWY-7323: super pathway of GDP-mannose-derived O-antigen building blocks biosynthesis IGHV3-30 ‒0.62012 5.2E–05 0.043212
COLANSYN-PWY: colanic acid building blocks biosynthesis RP11-16E12.2 ‒0.61959 0.00017 0.092741
ANAGLYCOLYSIS-PWY: glycolysis III (from glucose) IGHV2-70 ‒0.69299 2.94E–05 0.028746 6
CALVIN-PWY: Calvin-Benson-Bassham cycle IGHV2-70 ‒0.75205 9.6E–06 0.01349
NONOXIPENT-PWY: pentose phosphate pathway (non-oxidative branch) IGHV2-70 ‒0.75603 1.87E–05 0.021434
PWY-1042: glycolysis IV (plant cytosol) IGHV2-70 ‒0.73312 2.18E–06 0.00494
PWY-7242: D-fructuronate degradation IGHV2-70 ‒0.69802 8.1E–05 0.056949
COA-PWY: coenzyme A biosynthesis I MTND2P28 ‒0.61331 1.79E–05 0.020776 7
FAO-PWY: fatty acid β-oxidation I MTND2P28 ‒0.64143 2.21E–05 0.023794
PWY-5100: pyruvate fermentation to acetate and lactate II MTND2P28 ‒0.66359 5.47E–05 0.044043
PWY-5136: fatty acid β-oxidation II (peroxisome) MTND2P28 ‒0.61916 3.21E–05 0.030777
PWY-1269: CMP-3-deoxy-D-manno-octulosonate biosynthesis I Vd2 0.679672 0.000179 0.071033 8
PWY-1269: CMP-3-deoxy-D-manno-octulosonate biosynthesis I Vd2T 0.661191 0.000251 0.022565
PWY-1269: CMP-3-deoxy-D-manno-octulosonate biosynthesis I IGHV2-26 ‒0.63313 0.000189 0.098755
HEME-BIOSYNTHESIS-II: heme biosynthesis I (aerobic) IGKV1-17 ‒0.74011 4.13E–05 0.036607 9
PWY-5918: super pathway of heme biosynthesis from glutamate IGKV1-17 ‒0.71627 0.000159 0.087773
s__Streptococcus_parasanguinis KRTAP13-2 ‒0.6127 1.05E–05 0.006086 10
s__Streptococcus_parasanguinis RN7SL65P ‒0.62108 5.04E–06 0.003209
s__Dorea_formicigenerans CD8_TNFa_IFNg 0.651556 0.000876 0.036379 11
UniRef90_G1WU72: NO_NAME CD8_TNFa_IFNg 0.641326 6.26E–05 0.083128
PWY-5384: sucrose degradation IV (sucrose phosphorylase) AGAP12P 0.660269 2.54E–05 0.026031 12
PWY-5384: sucrose degradation IV (sucrose phosphorylase) NPIPB1P 0.648085 0.000185 0.098183
UniRef90_C9YMF0: Sigma-24 (Feci) IL1RN 0.810404 8.15E–06 0.074295 13
UniRef90_D4L1Z0: DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog IL1RN 0.807528 7.07E–06 0.068494
PWY-3001: super pathway of L-isoleucine biosynthesis I Treg_TNFa_IFNg ‒0.63367 0.000231 0.071033 14
THRESYN-PWY: super pathway of L-threonine biosynthesis Treg_TNFa_IFNg ‒0.72483 7.24E–05 0.050646
P461-PWY: hexitol fermentation to lactate, formate, ethanol and acetate SIGLEC12 0.722109 7.4E–05 0.053292 15
UniRef90_R6SAP9: Orotate phosphoribosyltransferase SIGLEC12 0.743519 2.73E–06 0.040374
FUC-RHAMCAT-PWY: super pathway of fucose and rhamnose degradation RP11-693J15.5 0.622961 0.000178 0.095618 16
UniRef90_R5DXN6: NO_NAME TMEM72 ‒0.6137 9.9E–06 0.081082 17
PWY-5695: urate biosynthesis/inosine 5-phosphate degradation IGHV3-53 ‒0.7541 0.000161 0.088313 18
UniRef90_R5J0A8: Transposase IS605 OrfB family central region SLC6A14 0.727059 9.13E–06 0.077542 19
UniRef90_R9HTU6: NO_NAME RPL6P12 0.644934 1.12E–05 0.087267 20
UniRef90_D4K3E4: Desulfoferrodoxin ferrous iron-binding domain IGLV5-45 0.677288 6.46E–06 0.065139 21
s__Odoribacter_splanchnicus PCK1 ‒0.67833 4.84E–05 0.020322 22
UniRef90_C7H7L8: NO_NAME LL22NC03-23C6.12 0.603595 6.12E–09 0.000802 23
Vd2T_TNFa_IFNg KLK10 0.719637 7.31E–09 2.1E–05 24
UniRef90_C4ZEM9: NO_NAME REG1A 0.653404 3.24E–07 0.010793 25
UniRef90_R5J281: NO_NAME Treg_TNFa 0.66736 2.24E–07 0.004274 26
UniRef90_A8SCB2: NO_NAME GSTA1 ‒0.64042 4E–06 0.052695 27
Treg_INFg_only FOS 0.640109 1.57E–05 0.015843 28
PWY-5345: super pathway of L-methionine biosynthesis (by sulfhydrylation) Teff_IFNg_Only ‒0.67739 0.000424 0.078253 29
P185-PWY: formaldehyde assimilation III (dihydroxyacetone cycle) IGLV4-60 ‒0.68048 9.42E–05 0.063081 30
UniRef90_V8CHB5: NO_NAME DSG3 0.644924 2.65E–06 0.039778 31
PWY0-1296: purine ribonucleosides degradation ALDH1L1 0.623461 0.000178 0.095618 32
HEMESYN2-PWY: heme biosynthesis II (anaerobic) Teff_Immune.Pop ‒0.6012 0.001917 0.065199 33
s__Alistipes_shahii ADAMTS4 0.607468 0.000263 0.071968 34
s__Bacteroidales_bacterium_ph8 IL22 0.621457 1.92E–07 0.000212 35
Significant associations in PSO1-associated network
activated.memory.CD8 RP11-299L17.3 0.650444 1.13E–06 0.00596 1
activated.nonMemory.CD8 RP11-299L17.3 0.650444 1.79E–07 0.001895
activeCD8 RP11-299L17.3 0.650444 2.14E–06 0.007538
UniRef90_D4JPG6: NO_NAME RP11-299L17.3 0.65273 1.51E–06 0.090737
UniRef90_U4D938: NO_NAME RP11-299L17.3 0.651584 1.37E–07 0.030625
UniRef90_D4LM01: Site-specific recombinase XerD activated.memory.CD8 0.804932 0.000156 0.095101
UniRef90_D4LWR3: RNA polymerase sigma factor, sigma-70 family activated.memory.CD8 0.712285 1.54E–05 0.033677
UniRef90_D4MWC2: Replication initiator protein A (RepA) N-terminus activated.memory.CD8 0.642109 3.2E–05 0.047927
UniRef90_U4D938: NO_NAME activated.memory.CD8 0.612961 3.6E–05 0.047962
UniRef90_D4LWR3: RNA polymerase sigma factor, sigma-70 family activated.memory.Teff 0.648507 2.11E–05 0.038011
UniRef90_C4Z761: Citrate synthase activeCD8 0.617548 0.000109 0.08439
UniRef90_G2T5D6: Glutathione synthase activeCD8 0.624565 3.18E–05 0.047927
s__Flavonifractor_plautii activated.nonMemory.Teff 0.666676 6.31E–10 1.56E–07 2
s__Ruminococcus_sp_5_1_39BFAA activated.nonMemory.Teff 0.616463 0.000705 0.069518
UniRef90_C6JCI4: NO_NAME activated.nonMemory.Teff 0.645614 0.000177 0.098154
UniRef90_D4LLE0: Aldehyde dehydrogenase, molybdenum-binding subunit apoprotein activated.nonMemory.Teff 0.660215 9.81E–05 0.082059
UniRef90_R5HR90: NO_NAME activated.nonMemory.Teff 0.635567 6.87E–05 0.069169
UniRef90_R5HVG1: NO_NAME activated.nonMemory.Teff 0.690686 1.74E–05 0.034534
UniRef90_R5I7T7: ATP-dependent 6-phosphofructokinase activated.nonMemory.Teff 0.695959 0.000192 0.098154
UniRef90_R5XT20: Rhamnulose-1-phosphate aldolase activated.nonMemory.Teff 0.706504 0.000132 0.092377
UniRef90_R6GH13: NO_NAME activated.nonMemory.Teff 0.731108 3.57E–05 0.047962
UniRef90_R6PH30: NO_NAME activated.nonMemory.Teff 0.682456 1.65E–05 0.034534
UniRef90_R6Q745: NO_NAME activated.nonMemory.Teff 0.742962 2.36E–05 0.040223
UniRef90_R7CD60: NO_NAME activated.nonMemory.Teff 0.695959 8.4E–05 0.076379
UniRef90_R7CD72: NO_NAME activated.nonMemory.Teff 0.695959 0.000145 0.092467
UniRef90_R7CDD0: NO_NAME activated.nonMemory.Teff 0.700709 0.000163 0.096324
UniRef90_R7CGR6: NO_NAME activated.nonMemory.Teff 0.685965 0.00013 0.092377
UniRef90_R7CGS0: NO_NAME activated.nonMemory.Teff 0.73592 0.000135 0.092377
UniRef90_R7CGX0: Nicotinate phosphoribosyltransferase activated.nonMemory.Teff 0.64437 0.000179 0.098154
UniRef90_R7CGX6: NO_NAME activated.nonMemory.Teff 0.607018 0.00012 0.09182
UniRef90_R7CH88: NO_NAME activated.nonMemory.Teff 0.697716 0.000174 0.098154
UniRef90_R7CIC0: NO_NAME activated.nonMemory.Teff 0.666676 0.000155 0.095101
UniRef90_R7CIF8: NO_NAME activated.nonMemory.Teff 0.64386 0.000128 0.092377
UniRef90_R7CK52: NO_NAME activated.nonMemory.Teff 0.741653 0.000141 0.092467
UniRef90_R7CLQ2: Cyclic pyranopterin monophosphate synthase accessory protein activated.nonMemory.Teff 0.674929 9.2E–05 0.080527
UniRef90_R7CLX2: NO_NAME activated.nonMemory.Teff 0.655537 0.000181 0.098154
UniRef90_R7CPD9: NO_NAME activated.nonMemory.Teff 0.652022 3.76E–05 0.048
UniRef90_R7CPY8: NO_NAME activated.nonMemory.Teff 0.721193 0.000124 0.092377
UniRef90_R7CR35: ATP synthase activated.nonMemory.Teff 0.698246 0.000102 0.082059
UniRef90_R7CRE2: Acetylglutamate kinase activated.nonMemory.Teff 0.700709 0.00019 0.098154
UniRef90_R7CSG7: NO_NAME activated.nonMemory.Teff 0.675439 8.46E–05 0.076379
UniRef90_R7CSS1: NO_NAME activated.nonMemory.Teff 0.734623 0.000134 0.092377
UniRef90_R7DCE8: NO_NAME activated.nonMemory.Teff 0.601055 5.27E–05 0.058851
UniRef90_R7NEY7: Acetyltransferases activated.nonMemory.Teff 0.625457 1.66E–06 0.008485
UniRef90_T5LV87: IS605 OrfB family transposase activated.nonMemory.Teff 0.624561 0.000135 0.092377
UniRef90_T5M0M6: NO_NAME activated.nonMemory.Teff 0.711034 6.03E–05 0.062774
UniRef90_E1YTP4: NO_NAME activated.nonMemory.Teff 0.790135 5.17E–07 0.003527 3
UniRef90_R7CII3: NO_NAME activated.nonMemory.Teff 0.670823 0.000184 0.098154
UniRef90_R7CQN6: TrkA-N domain-containing protein activated.nonMemory.Teff 0.699664 0.000171 0.098154
UniRef90_D4LQI2: Site-specific recombinases, DNA invertase Pin homologs Teff_IL17_IL22 0.652583 2.91E–06 0.015436
UniRef90_C6J953: NO_NAME Teff_IL17_only 0.671967 1.62E–06 0.011888
UniRef90_C6JBL1: NO_NAME Teff_IL17_only 0.610238 4.71E–05 0.065888
UniRef90_C6JEF2: NO_NAME Teff_IL17_only 0.62527 2.19E–05 0.047594
UniRef90_D4LQI1: Site-specific recombinases, DNA invertase Pin homologs Teff_IL17_only 0.698422 4.94E–05 0.066521
UniRef90_D4LQI2: Site-specific recombinases, DNA invertase Pin homologs Teff_IL17_only 0.627224 3.5E–06 0.016735
UniRef90_E1YTP4: NO_NAME Teff_IL17_only 0.62082 6.42E–06 0.022067
UniRef90_R5XAV3: Heavy-metal-associated domain Teff_IL17_only 0.62566 9.01E–07 0.008609
UniRef90_R7CFY1: NO_NAME Teff_IL17_only 0.669696 2.91E–05 0.054164
UniRef90_R7CHB7: Na+/H+ antiporter NhaC Teff_IL17_only 0.811625 1.33E–05 0.035418
UniRef90_R7CII3: NO_NAME Teff_IL17_only 0.610643 0.000114 0.091508
UniRef90_R7CMK6: NO_NAME Teff_IL17_only 0.637328 1.29E–07 0.002051
UniRef90_R7CN26: NO_NAME Teff_IL17_only 0.666082 3.98E–06 0.017267
UniRef90_R7CQN6: TrkA-N domain-containing protein Teff_IL17_only 0.61839 0.00011 0.090629
UniRef90_A5ZNM4: NO_NAME Teff_IL17_IL22 0.734266 5.1E–06 0.019503 4
UniRef90_A5ZYV3: NO_NAME Teff_IL17_IL22 0.706294 3.54E–05 0.06035
UniRef90_A5ZYV6: NO_NAME Teff_IL17_IL22 0.686516 2.57E–06 0.015322
UniRef90_C6JC21: NO_NAME Teff_IL17_IL22 0.607808 6.47E–06 0.022067
UniRef90_D4JAB3: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Teff_IL17_IL22 0.794387 0.000109 0.090629
UniRef90_D4LKT7: 50S ribosomal protein L7/L12 Teff_IL17_IL22 0.684624 0.000117 0.091508
UniRef90_D4LRE4: Transcriptional regulator, BadM/Rrf2 family Teff_IL17_IL22 0.666693 9.86E–05 0.086726
UniRef90_D4LVZ1: Predicted transcriptional regulators Teff_IL17_IL22 0.766035 8.23E–07 0.008609
UniRef90_D4MTV2: Transcriptional regulator, MerR family Teff_IL17_IL22 0.713542 5.75E–05 0.073251
UniRef90_D4MUD3: Transcriptional regulator, MarR family Teff_IL17_IL22 0.729829 1.16E–06 0.009737
UniRef90_F7JEX2: NO_NAME Teff_IL17_IL22 0.711285 3.92E–06 0.017267
UniRef90_R5Z6G3: NO_NAME Teff_IL17_IL22 0.678483 2.85E–06 0.015436
UniRef90_R7CCT5: NO_NAME Teff_IL17_IL22 0.678393 0.000148 0.099236
UniRef90_D4MUD3: Transcriptional regulator, MarR family Teff_IL17_only 0.75747 8.66E–08 0.002044
s__Bacteroides_thetaiotaomicron CD300E 0.640982 2.63E–05 0.02332 5
UniRef90_G2T376: NO_NAME CXCL2 0.735024 1.52E–06 0.090737
s__Bacteroides_thetaiotaomicron CXCL3 0.704029 3.68E–06 0.007238
UniRef90_G2T376: NO_NAME CXCL3 0.699686 6.32E–07 0.045297
UniRef90_G2T5J9: NO_NAME CXCL3 0.727956 7.33E–07 0.0507
UniRef90_G2T376: NO_NAME LRFN5 0.657281 4.08E–07 0.040956
s__Bacteroides_thetaiotaomicron SOCS3 0.704029 8.85E–05 0.050575
UniRef90_D4LVH8: KaiC activated.memory.CD8 0.78459 0.000144 0.092467 6
UniRef90_R9JXY1: 50S ribosomal protein L33 activated.nonMemory.Teff 0.648507 0.000165 0.096324
UniRef90_A7B829: NO_NAME Active.Teff 0.620145 0.000188 0.098154
UniRef90_D4LVH8: KaiC Active.Teff 0.697716 0.000175 0.098154
UniRef90_G2T5D0: NO_NAME Active.Teff 0.651408 0.000155 0.095101
UniRef90_K1S8B5: Transcriptional regulator Active.Teff 0.739437 0.000158 0.09531
UniRef90_R9JXY1: 50S ribosomal protein L33 Active.Teff 0.669014 0.00014 0.092467
UniRef90_U2PAU4: NO_NAME Active.Teff 0.870181 5.14E–07 0.003527
s__Barnesiella_intestinihominis LL22NC03-23C6.12 0.651584 9.5E–05 0.052803 7
UniRef90_C7H7L9: ABC transporter, ATP-binding protein LL22NC03-23C6.12 0.65273 2.34E–07 0.036053
s__Barnesiella_intestinihominis SERPINA9 0.747806 3.18E–05 0.026686
s__Eubacterium_hallii GSTA1 0.72028 0.000187 0.078443 8
UniRef90_E2ZGA1: NO_NAME GSTA1 ‒0.82312 1.06E–06 0.071004
s__Eubacterium_ventriosum Vd2T_TNFa_only 0.797189 5.33E–05 0.006695 9
UniRef90_B0NZF6: NO_NAME Vd2T_TNFa_only 0.64675 0.000105 0.090542
UniRef90_D4M5F3: dTDP-glucose pyrophosphorylase memory.Teff ‒0.88422 0.000101 0.082059 10
UniRef90_D4M5F3: dTDP-glucose pyrophosphorylase nonMemory.Teff 0.880707 5.17E–05 0.058792
DZ_duration CD8_IL17_IL22 0.654946 0.000478 0.040147 11
PWY-5104: L-isoleucine biosynthesis IV DZ_duration 0.736492 0.000281 0.068952
UniRef90_B0G2Q7: NO_NAME Treg_IL17_IL22 0.776803 7.01E–05 0.077728 12
UniRef90_D4J5V6: Site-specific recombinase XerD Treg_IL17_IL22 0.693832 9.86E–05 0.086726
UniRef90_A5ZSX2: NO_NAME CD8_TNFa_IFNg 0.907182 7.34E–05 0.077728 13
UniRef90_D4JAA1: Phage integrase family CD8_TNFa_IFNg 0.795496 6.81E–05 0.077728
s__Parabacteroides_distasonis IL17A 0.649429 0.000219 0.085842 14
s__Parabacteroides_distasonis LINC00939 0.751742 2.07E–05 0.020128
s__Bacteroides_dorei FOSB 0.605649 4.51E–05 0.033931 15
s__Bacteroides_dorei Treg_IL22_only 0.643114 3.18E–05 0.004358
Treg_INFg_only RP11-301M17.1 0.650444 2.22E–06 0.009133 16
UniRef90_G2SYP7: NO_NAME Teff_TNFa_only 0.704243 5.65E–06 0.020765 17
UniRef90_C4Z763: GTP pyrophosphokinase Teff_TNFa_INFg 0.804196 0.000117 0.091508 18
PWY0-1297: superpathway of purine deoxyribonucleosides degradation PASI 0.713137 1.85E–05 0.018036 19
UniRef90_C0FPA9: BAAT/acyl-CoA thioester hydrolase C-terminal domain protein nonMemory.CD8 ‒0.87834 0.000123 0.092377 20
s__Alistipes_putredinis CD55 0.881119 0.000117 0.059771 21
s__Dorea_formicigenerans TRHDE 0.895105 4.16E–05 0.032046 22
s__Coprococcus_comes CCDC85A ‒0.63398 0.000222 0.086043 23
s__Lachnospiraceae_bacterium_3_1_46FAA UCA1 0.609458 0.000162 0.072164 24
THRESYN-PWY: super pathway of L-threonine biosynthesis Treg_TNFa_IFNg ‒0.85365 7.05E–06 0.016049 25
UniRef90_C7H2P0: NO_NAME CD8_TNFa_only 0.704029 8.19E–05 0.079819 26
s__Roseburia_inulinivorans CD177 ‒0.83916 1.39E–06 0.003509 27
PYRIDNUCSAL-PWY: NAD salvage pathway I URAD 0.882718 1.02E–07 0.005333 28
Significant associations in PSO2-associated network
BIOTIN-BIOSYNTHESIS-PWY: biotin biosynthesis I CYP2B7P 0.833333 2.98E–05 0.009035 1
FASYN-ELONG-PWY: fatty acid elongation -- saturated CYP2B7P 0.833333 1.4E–05 0.005053
FASYN-INITIAL-PWY: super pathway of fatty acid biosynthesis initiation (E. coli) CYP2B7P 0.826362 2.64E–05 0.008035
GLUDEG-I-PWY: GABA shunt CYP2B7P 0.714286 0.000278 0.074586
PWY-5022: 4-aminobutanoate degradation V CYP2B7P 0.714286 0.000334 0.087365
PWY-5971: palmitate biosynthesis II (bacteria and plants) CYP2B7P 0.833333 2.8E–05 0.008503
PWY-6113: superpathway of mycolate biosynthesis CYP2B7P 0.833333 4.57E–05 0.013734
PWY-6282: palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) CYP2B7P 0.833333 7.21E–05 0.021414
PWY-6284: super pathway of unsaturated fatty acids biosynthesis (E. coli) CYP2B7P 0.833333 4.07E–05 0.012269
PWY-6519: 8-amino-7-oxononanoate biosynthesis I CYP2B7P 0.833333 3.09E–05 0.009339
PWY-7388: octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) CYP2B7P 0.833333 1.83E–05 0.006357
PWY-7664: oleate biosynthesis IV (anaerobic) CYP2B7P 0.833333 1.18E–05 0.004438
PWY0-862: (5Z)-dodec-5-enoate biosynthesis CYP2B7P 0.833333 2.54E–05 0.007747
PWYG-321: mycolate biosynthesis CYP2B7P 0.833333 1.31E–05 0.004806
BIOTIN-BIOSYNTHESIS-PWY: biotin biosynthesis I STC1 –0.7619 0.00013 0.03689
FASYN-ELONG-PWY: fatty acid elongation -- saturated STC1 –0.7619 0.000173 0.047907
FASYN-INITIAL-PWY: super pathway of fatty acid biosynthesis initiation (E. coli) STC1 –0.7545 0.000271 0.073002
PWY-5971: palmitate biosynthesis II (bacteria and plants) STC1 ‒0.7619 0.000209 0.05735
PWY-6113: super pathway of mycolate biosynthesis STC1 ‒0.7619 0.000287 0.076805
PWY-6282: palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) STC1 ‒0.7619 0.00028 0.075069
PWY-6284: super pathway of unsaturated fatty acids biosynthesis (E. coli) STC1 ‒0.7619 0.000347 0.090509
PWY-6519: 8-amino-7-oxononanoate biosynthesis I STC1 ‒0.7619 0.0002 0.055236
PWY-7388: octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) STC1 ‒0.7619 0.00016 0.044499
PWY-7664: oleate biosynthesis IV (anaerobic) STC1 ‒0.7619 0.000235 0.063921
PWY0-862: (5Z)-dodec-5-enoate biosynthesis STC1 ‒0.7619 0.000229 0.062421
PWYG-321: mycolate biosynthesis STC1 ‒0.7619 0.00012 0.0343
s__Bacteroides_ovatus Teff_TNFa_only 0.666667 0.000994 0.091836 2
s__Bacteroides_ovatus Vd2T_IL17_only 0.761905 0.00021 0.043201
UniRef90_C0FN95: NO_NAME Vd2T_IL17_only 0.880952 5.48E–07 0.026184
UniRef90_D6E3G6: Site-specific recombinase XerD Vd2T_IL17_only 0.90368 1.25E–07 0.011927
ANAEROFRUCAT-PWY: homolactic fermentation FOS ‒0.97619 0.000119 0.034027 3
GLYCOLYSIS: glycolysis I (from glucose 6-phosphate) FOS ‒0.95238 8.01E–05 0.023227
PWY-5484: glycolysis II (from fructose 6-phosphate) FOS ‒0.95238 5.05E–05 0.015132
ANAEROFRUCAT-PWY: homolactic fermentation PDE4C ‒0.90476 9.72E–05 0.028114
ARGSYN-PWY: L-arginine biosynthesis I (via L-ornithine) PASI 0.754505 0.001298 0.055236 4
PENTOSE-P-PWY: pentose phosphate pathway PASI 0.833333 0.002607 0.055236
PWY-5154: L-arginine biosynthesis III (via N-acetyl-L-citrulline) PASI 0.785714 0.001279 0.055236
PWY-7400: L-arginine biosynthesis IV (archaebacteria) PASI 0.754505 0.001234 0.055236
ARGSYN-PWY: L-arginine biosynthesis I (via L-ornithine) XIST ‒0.64672 7.14E–06 0.00271
ARGSYNBSUB-PWY: L-arginine biosynthesis II (acetyl cycle) XIST ‒0.92857 4.15E–06 0.001618
GLUTORN-PWY: L-ornithine biosynthesis XIST ‒0.6627 2.01E–07 9.8E–05
PWY-5154: L-arginine biosynthesis III (via N-acetyl-L-citrulline) XIST ‒0.63474 1.07E–05 0.004031
PWY-7400: L-arginine biosynthesis IV (archaebacteria) XIST ‒0.62655 1.07E–05 0.004046
PWY-6121: 5-aminoimidazole ribonucleotide biosynthesis I BMX ‒0.95238 0.000205 0.056554 5
PWY-6122: 5-aminoimidazole ribonucleotide biosynthesis II BMX ‒0.97619 0.000225 0.061454
PWY-6277: super pathway of 5-aminoimidazole ribonucleotide biosynthesis BMX ‒0.97619 0.000225 0.061454
PWY-6121: 5-aminoimidazole ribonucleotide biosynthesis I CCDC129 ‒0.88095 0.000105 0.030152
PWY-6122: 5-aminoimidazole ribonucleotide biosynthesis II CCDC129 ‒0.90476 0.000107 0.030556
PWY-6277: superpathway of 5-aminoimidazole ribonucleotide biosynthesis CCDC129 ‒0.90476 0.000107 0.030556
PWY-6121: 5-aminoimidazole ribonucleotide biosynthesis I SH2D6 ‒0.97619 2.49E–05 0.007595
PWY-6122: 5-aminoimidazole ribonucleotide biosynthesis II SH2D6 ‒0.95238 7.94E–05 0.023078
PWY-6277: superpathway of 5-aminoimidazole ribonucleotide biosynthesis SH2D6 ‒0.95238 7.94E–05 0.023078
PWY-6121: 5-aminoimidazole ribonucleotide biosynthesis I SH2D7 ‒0.95238 0.000325 0.085378
PWY-6122: 5-aminoimidazole ribonucleotide biosynthesis II SH2D7 ‒0.97619 0.000326 0.08554
PWY-6277: super pathway of 5-aminoimidazole ribonucleotide biosynthesis SH2D7 ‒0.97619 0.000326 0.08554
P461-PWY: hexitol fermentation to lactate, formate, ethanol and acetate MT1X ‒0.85714 7.8E–05 0.022737 6
P461-PWY: hexitol fermentation to lactate, formate, ethanol, and acetate MYBL1 ‒0.90476 0.000309 0.081754
P461-PWY: hexitol fermentation to lactate, formate, ethanol, and acetate NTRK2 ‒0.95238 0.000321 0.084551
s__Clostridium_bartlettii IL17F 0.76835 0.000202 0.059482 7
s__Veillonella_unclassified IL17F 0.76835 2.91E–05 0.011329
s__Clostridium_bartlettii RN7SL301P 0.76835 0.00012 0.038644
s__Veillonella_unclassified RN7SL301P 0.76835 7.23E–05 0.025955
s__Eggerthella_lenta Vd2 0.89822 0.000353 0.054394 8
s__Flavonifractor_plautii Vd2 0.785714 0.000613 0.072663
s__Eggerthella_lenta RP11-707O23.5 0.76835 1.96E–06 0.001075
s__Flavonifractor_plautii RP11-707O23.5 0.763763 0.000134 0.04259
s__Eubacterium_siraeum Vd2T_IL22_only 0.814386 0.000264 0.048712 9
s__Eubacterium_siraeum IL17C 0.76835 7.73E–06 0.003364
s__Subdoligranulum_unclassified IRX2 0.754505 0.000291 0.083959 10
s__Subdoligranulum_unclassified PAX8-AS1 ‒0.83333 0.000316 0.087851
s__Roseburia_hominis C5orf17 0.904762 0.000139 0.043995 11
s__Roseburia_hominis RP11-726G1.1 0.904762 0.000122 0.038958
GALACTUROCAT-PWY: D-galacturonate degradation I GHR 0.928571 0.000275 0.073927 12
PWY-6507: 4-deoxy-L-threo-hex-4-enopyranuronate degradation GHR 0.97619 5.83E–05 0.017377
CITRULBIO-PWY: L-citrulline biosynthesis PCK1 0.904762 0.00033 0.086443 13
PWY-4984: urea cycle PCK1 0.904762 0.000355 0.092057
PWY-6305: putrescine biosynthesis IV CXCL8 0.97619 0.000123 0.034844 14
PWY-6305: putrescine biosynthesis IV IGHV4-31 0.928571 0.000159 0.044272
FAO-PWY: fatty acid β-oxidation I IGKV1D-16 0.946125 0.000305 0.080971 15
PWY-5136: fatty acid β-oxidation II (peroxisome) IGKV1D-16 0.952381 7.44E–05 0.022051
P42-PWY: incomplete reductive TCA cycle IGLV7-46 ‒0.97619 0.000353 0.091828 16
PWY-5104: L-isoleucine biosynthesis IV IGLV7-46 ‒0.95238 0.000101 0.029049
s__Lachnospiraceae_bacterium_1_4_56FAA CD8_IL22_only 0.809524 0.000137 0.036152 17
s__Lachnospiraceae_bacterium_1_4_56FAA Teff_TNFa_INFg 0.718576 6.25E–05 0.020997
PWY-5189: tetrapyrrole biosynthesis II (from glycine) CA1 ‒0.78571 0.000311 0.082075 18
PWY-5189: tetrapyrrole biosynthesis II (from glycine) CD274 0.928571 0.000299 0.079439
FOLSYN-PWY: super pathway of tetrahydrofolate biosynthesis and salvage TMEM37 0.934148 3.07E–06 0.001317 19
PWY-6612: superpathway of tetrahydrofolate biosynthesis TMEM37 0.904762 4.47E–06 0.001739
Treg_IL17_only FCRL1 ‒0.97619 6.99E–05 0.041248 20
Treg_IL17_only FCRLA ‒1 0.000158 0.087172
PWY-6969: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) REG1A ‒0.76376 0.000365 0.094544 21
s__Bacteroides_xylanisolvens REG1A 0.736989 0.000162 0.048778
GLCMANNANAUT-PWY: super pathway of N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminate degradation C11orf86 ‒0.83333 5.42E–06 0.002104 22
GLUCONEO-PWY: gluconeogenesis I IGLV3-10 ‒0.7619 0.000271 0.073002 23
s__Ruminococcus_bromii IGHM 0.904762 1.28E–05 0.005526 24
PWY-621: sucrose degradation III (sucrose invertase) CLCA4 ‒0.97619 1.29E–05 0.00476 25
PWY-2941: L-lysine biosynthesis II NLGN4Y 0.912328 0.000273 0.073524 26
PHOSLIPSYN-PWY: super pathway of phospholipid biosynthesis I (bacteria) IGLV5-37 ‒0.90476 0.000222 0.060934 27
UniRef90_B0GA46: NO_NAME CD8_TNFa_IFNg 0.8485 2.77E–06 0.088269 28
TRNA-CHARGING-PWY: tRNA charging CHIT1 ‒0.92857 1.07E–05 0.004046 29
RHAMCAT-PWY: L-rhamnose degradation I DZ_duration 0.886243 0.00443 0.078996 30
s__Clostridium_bolteae Active.Teff ‒0.87427 0.000195 0.092483 31
PWY0-1297: superpathway of purine deoxyribonucleosides degradation MYEOV 0.904762 3.78E–05 0.011407 32
NONOXIPENT-PWY: pentose phosphate pathway (non-oxidative branch) CLIC6 0.904762 0.000182 0.050256 33
PWY-3001: super pathway of L-isoleucine biosynthesis I CIDEC ‒0.88095 0.000207 0.056999 34
s__Bilophila_wadsworthia NLRP2 ‒0.95238 4.72E–05 0.018207 35
PWY-5005: biotin biosynthesis II KRT8P36 0.922172 0.000142 0.040129 36
PWY0-1061: superpathway of L-alanine biosynthesis RP11-575F12.2 0.970077 0.000254 0.068804 37
PWY0-1296: purine ribonucleosides degradation SULT1C2 ‒0.97619 0.000106 0.030556 38
MET-SAM-PWY: super pathway of S-adenosyl-L-methionine biosynthesis FRMD1 ‒0.80952 0.000175 0.048401 39
LACTOSECAT-PWY: lactose and galactose degradation I IGHV1-3 0.952381 0.000237 0.064542 40
s__Bilophila_unclassified RPS6KA2-AS1 ‒1 1.82E–05 0.007734 41
PWY-7383: anaerobic energy metabolism (invertebrates, cytosol) IGLV4-60 ‒0.92857 0.000302 0.080129 42
HEME-BIOSYNTHESIS-II: heme biosynthesis I (aerobic) RP11-958N24.2 0.788009 0.000292 0.077896 43
PWY-7234: inosine-5-phosphate biosynthesis III HERC2P4 ‒0.92857 0.000167 0.0464 44
PWY0-162: super pathway of pyrimidine ribonucleotides de novo biosynthesis ARL14 ‒0.97008 6.97E–05 0.020733 45
PWY-7229: superpathway of adenosine nucleotides de novo biosynthesis I CTAGE15 0.857143 0.000298 0.079314 46
Vd2T_IFNg_only IGLC7 0.880952 0.000167 0.08878 47
PWY-6897: thiamin salvage II MME-AS1 0.76835 0.000346 0.09024 48
PWY-5030: L-histidine degradation III AC131056.3 0.952381 0.000379 0.097971 49
s__Eubacterium_eligens RP11-259G18.3 ‒0.95181 6.08E–05 0.022759 50
Treg_IL17_IL22 IGKV1D-43 0.730552 6.75E–05 0.041248 51
s__Lachnospiraceae_bacterium_7_1_58FAA ZBTB16 0.928571 0.000347 0.095663 52
s__Coprococcus_catus THNSL2 1 5.97E–05 0.02245 53
s__Erysipelotrichaceae_bacterium_6_1_45 PTGS2 ‒0.83333 0.000359 0.098475 54
s__Bifidobacterium_longum Vd2T_TNFa_only ‒0.91573 0.000601 0.072663 55
List of significant associations in PSO3 associated network
P122-PWY: heterolactic fermentation EDDM3DP 0.664211 1.49E–05 0.022213 1
P122-PWY: heterolactic fermentation RP11-100G15.10 0.664211 1.49E–05 0.022213
PWY-5083: NAD/NADH phosphorylation and dephosphorylation EDDM3DP 0.695608 4.42E–07 0.001001
PWY-5083: NAD/NADH phosphorylation and dephosphorylation RP11-100G15.10 0.695608 4.42E–07 0.001001
PWY-821: super pathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) RP11-100G15.10 0.695608 7.39E–05 0.070103
PWY-821: super pathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) EDDM3DP 0.695608 7.39E–05 0.070103
PWY0-1061: superpathway of L-alanine biosynthesis RP11-100G15.10 0.654654 9.11E–05 0.081919
PWY0-1061: superpathway of L-alanine biosynthesis EDDM3DP 0.654654 9.11E–05 0.081919
s__Bacteroides_xylanisolvens EDDM3DP 0.654654 0.000129 0.063831
s__Bacteroides_xylanisolvens RP11-100G15.10 0.654654 0.000129 0.063831
s__Haemophilus_parainfluenzae EDDM3DP 0.654654 3.59E–07 0.000407
s__Haemophilus_parainfluenzae RP11-100G15.10 0.654654 3.59E–07 0.000407
PWY-5188: tetrapyrrole biosynthesis I (from glutamate) MYBL1 ‒1 1.56E–05 0.022439 2
PWY-5188: tetrapyrrole biosynthesis I (from glutamate) PAX5 ‒1 4.29E–05 0.046051
PWY-5188: tetrapyrrole biosynthesis I (from glutamate) AFF2 ‒1 1.32E–05 0.020625
PWY-5188: tetrapyrrole biosynthesis I (from glutamate) TCL1A ‒0.88571 1.28E–05 0.020213
PWY-5188: tetrapyrrole biosynthesis I (from glutamate) CD79B ‒0.88571 3.53E–05 0.040084
PWY-5345: superpathway of L-methionine biosynthesis (by sulfhydrylation) PWP2 ‒0.94286 1.25E–05 0.019878 3
PWY-5345: super pathway of L-methionine biosynthesis (by sulfhydrylation) IGKV1-9 ‒0.94286 8.57E–05 0.078976
SULFATE-CYS-PWY: super pathway of sulfate assimilation and cysteine biosynthesis IGKV1-9 ‒0.89865 8.22E–05 0.076628
COBALSYN-PWY: adenosylcobalamin salvage from cobinamide I ATP13A5 ‒1 8.76E–05 0.079978 4
DTDPRHAMSYN-PWY: dTDP-L-rhamnose biosynthesis I ATP13A5 ‒1 3.25E–05 0.037635
DTDPRHAMSYN-PWY: dTDP-L-rhamnose biosynthesis I RGS13 ‒0.94286 6.46E–05 0.063204
s__Roseburia_intestinalis IL36RN 0.845154 7.21E–05 0.042737 5
s__Roseburia_intestinalis SLC44A5 0.771429 0.000123 0.061427
s__Roseburia_intestinalis RP11-313J2.1 ‒0.82857 6.98E–05 0.041714
s__Lachnospiraceae_bacterium_7_1_58FAA RP11-462B18.1 0.654654 0.000174 0.083495 6
s__Lachnospiraceae_bacterium_7_1_58FAA TM4SF4 0.885714 3.85E–05 0.024936
s__Lachnospiraceae_bacterium_7_1_58FAA IGHV3-66 ‒1 6.57E–06 0.005182
GOLPDLCAT-PWY: superpathway of glycerol degradation to 1,3-propanediol NARF ‒1 0.000113 0.097624 7
GOLPDLCAT-PWY: superpathway of glycerol degradation to 1,3-propanediol PNLIPRP2 ‒1 4.67E–05 0.04818
MET-SAM-PWY: superpathway of S-adenosyl-L-methionine biosynthesis TMEM150B (DRAM-3 regulate autophagy) 1 3.53E–05 0.040084 8
PWY-5347: superpathway of L-methionine biosynthesis (transsulfuration) TMEM150B 1 8.06E–05 0.075717
FAO-PWY: fatty acid β-oxidation I TEKT4P2 ‒1 2.74E–05 0.035602 9
PWY-5136: fatty acid β-oxidation II (peroxisome) TEKT4P2 ‒1 3.71E–05 0.040923
UniRef90_A7B4W0: NO_NAME AQP5 0.970588 4.31E–07 0.015343 10
UniRef90_D6DY27: ABC-type antimicrobial peptide transport system, ATPase component AQP5 0.955882 1.67E–06 0.057497
UniRef90_C6JCY5: NO_NAME IGLV4-60 ‒0.98561 2.08E–06 0.070312 11
NAD-BIOSYNTHESIS-II: NAD salvage pathway II NLGN4Y 0.941124 7.1E–05 0.068116 12
CALVIN-PWY: Calvin-Benson-Bassham cycle HBEGF 1 7.11E–05 0.068116 13
GLUCONEO-PWY: gluconeogenesis I RP11-575F12.3 1 7.47E–06 0.013124 14
PWY-5097: L-lysine biosynthesis VI RP11-30P6.6 ‒1 4.54E–05 0.047844 15
PYRIDNUCSYN-PWY: NAD biosynthesis I (from aspartate) RP11-747H7.3 1 5.69E–05 0.055963 16
UniRef90_G1WWG9: NO_NAME CD55 1 2.77E–06 0.090568 17
PWY-5005: biotin biosynthesis II TDRD1 0.941124 8.24E–05 0.076628 18
OANTIGEN-PWY: O-antigen building blocks biosynthesis (E. coli) ISG15 1 4.61E–05 0.048107 19
UniRef90_D4L1Y1: Site-specific recombinases, DNA invertase Pin homologs SERPINA9 ‒1 1.8E–08 0.000665 20
PWY-2941: L-lysine biosynthesis II PI15 0.828571 4.83E–05 0.049266 21
PWY4LZ-257: superpathway of fermentation (Chlamydomonas reinhardtii) IGLC7 ‒0.94286 8.84E–05 0.080307 22
UniRef90_D4KBZ1: Ribonuclease H HRCT1 ‒1 2.95E–06 0.094916 23
UniRef90_C7H3L3: NO_NAME FOSB ‒0.95618 1.65E–06 0.057497 24
CRNFORCAT-PWY: creatinine degradation I VWA5B1 1 5.56E–06 0.010772 25
s__Anaerostipes_hadrus RP11-424G14.1 0.845154 2.53E–07 0.000295 26

Abbreviations: adj, adjusted; Cor, correlation value.