Supplementary Table S7.
List of Microbial Metacyc Pathways that Are Differentially Abundant between Different Subgroups in the Cohort
| MetaCyc_Pathway | Base Mean | Log2 Fold Change | P-Value | Padj | Comparison Pair |
|---|---|---|---|---|---|
| NAD-BIOSYNTHESIS-II: NAD salvage pathway II | 6.885975523 | ‒2.032470385 | 0.004596 | 0.081003 | c2c1 |
| POLYAMINSYN3-PWY: super pathway of polyamine biosynthesis II | 16.58305195 | ‒2.61298583 | 0.002204 | 0.069068 | c2c1 |
| PWY-5121: superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) | 39.92534701 | ‒1.094952419 | 0.003983 | 0.081003 | c2c1 |
| PWY-5384: sucrose degradation IV (sucrose phosphorylase) | 6.824519225 | ‒3.287493629 | 0.0009 | 0.061079 | c2c1 |
| PWY-6147: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I | 54.32244565 | ‒0.893067591 | 0.002654 | 0.074673 | c2c1 |
| PWY-6167: flavin biosynthesis II (archaea) | 5.972757342 | ‒5.596005317 | 0.005971 | 0.098575 | c2c1 |
| PWY-6270: isoprene biosynthesis I | 88.15679759 | ‒1.066870021 | 0.006642 | 0.098575 | c2c1 |
| PWY-6859: all-trans-farnesol biosynthesis | 4.012058217 | ‒3.717715695 | 0.001083 | 0.061079 | c2c1 |
| PWY-7392: taxadiene biosynthesis (engineered) | 9.386270018 | ‒3.60306079 | 0.000283 | 0.042061 | c2c1 |
| PWY-7560: methylerythritol phosphate pathway II | 79.44418324 | ‒1.069297573 | 0.007032 | 0.099156 | c2c1 |
| ANAEROFRUCAT-PWY: homolactic fermentation | 143.8794075 | 0.779635572 | 0.0046 | 0.097618 | c2c3 |
| COLANSYN-PWY: colanic acid building blocks biosynthesis | 35.8384929 | 1.550221291 | 0.0044 | 0.097618 | c2c3 |
| HEXITOLDEGSUPER-PWY: superpathway of hexitol degradation (bacteria) | 54.54908312 | 0.909153433 | 0.002063 | 0.066483 | c2c3 |
| OANTIGEN-PWY: O-antigen building blocks biosynthesis (E. coli) | 99.70191306 | ‒1.121948089 | 0.006771 | 0.097618 | c2c3 |
| PHOSLIPSYN-PWY: superpathway of phospholipid biosynthesis I (bacteria) | 70.46008483 | 1.331355977 | 0.001855 | 0.066483 | c2c3 |
| PWY4FS-7: phosphatidylglycerol biosynthesis I (plastidic) | 51.5490991 | 1.391404667 | 0.006811 | 0.097618 | c2c3 |
| PWY-5101: L-isoleucine biosynthesis II | 66.49625492 | 1.214578922 | 0.005292 | 0.097618 | c2c3 |
| PWY-6168: flavin biosynthesis III (fungi) | 172.2879499 | 0.689038903 | 0.005629 | 0.097618 | c2c3 |
| PWY-7323: superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis | 25.89416668 | 1.771497516 | 0.002522 | 0.067784 | c2c3 |
| UDPNAGSYN-PWY: UDP-N-acetyl-D-glucosamine biosynthesis I | 67.18613175 | ‒1.506925835 | 0.001515 | 0.066483 | c2c3 |
| ARG+POLYAMINE-SYN: super pathway of arginine and polyamine biosynthesis | 69.58601257 | ‒0.960789029 | 0.000298 | 0.042061 | c2c1 |
| ARG+POLYAMINE-SYN: super pathway of arginine and polyamine biosynthesis | 69.58601257 | ‒1.05230553 | 0.000918 | 0.066483 | c2c3 |
| ARGININE-SYN4-PWY: L-ornithine de novo biosynthesis | 91.08538996 | 1.466876718 | 0.001004 | 0.066483 | c2c3 |
| ARGININE-SYN4-PWY: L-ornithine de novo biosynthesis | 91.08538996 | 1.144773909 | 0.001917 | 0.069068 | c2c1 |
| PWY-6471: peptidoglycan biosynthesis IV (Enterococcus faecium) | 10.68397596 | ‒2.509515632 | 0.004524 | 0.081003 | c2c1 |
| PWY-6471: peptidoglycan biosynthesis IV (Enterococcus faecium) | 10.68397596 | ‒3.293509459 | 0.001507 | 0.066483 | c2c3 |
| PYRIDOXSYN-PWY: pyridoxal 5-phosphate biosynthesis I | 83.95260245 | 1.49487838 | 0.002165 | 0.066483 | c2c3 |
| PYRIDOXSYN-PWY: pyridoxal 5-phosphate biosynthesis I | 83.95260245 | 1.201030452 | 0.002913 | 0.074673 | c2c1 |
Abbreviation: adj, adjusted.