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. 2022 Jun 21;10(6):e004226. doi: 10.1136/jitc-2021-004226

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Immunophenotyping of peripheral blood mononuclear cells using markers for T-cell activation and proliferation (N=323) and cytokine profiling (N=468) of plasma samples taken at baseline and after 4 weeks of treatment. Shown are proliferating CD8⁺/PD-1⁺ T cells (A), activated cytotoxic CD8⁺ T cells (B), and plasma IFN-γ (C). CD, cluster of differentiation; HLA, human leukocyte antigen; IFN, interferon; PD-1, programmed death receptor 1; placebo-DabTram, placebo plus dabrafenib and trametinib; sparta-DabTram, spartalizumab plus dabrafenib and trametinib.