Table 2.
Capture–recapture analysis of all invasive meningococcal disease cases reported to the SDR and MRS stratified by characteristics, Catalonia 2011–2015
| Records in SDR, n | Records in MRS, n | Matched records | Calculated unreported cases | Estimated total number of cases (95% CI) |
Sensitivity SDR (%) (95% CI) |
Sensitivity MRS (%) (95% CI) |
Difference in sensitivities (%) | P value | |
| All cases | 212 | 202 | 137 | 36 | 313 (295 to 330) | 67.9 (62.7 to 73.1) | 64.7 (59.4 to 70.0) | 3.2 | <0.001 |
| Age group | |||||||||
| <15 years | 131 | 126 | 87 | 20 | 190 (177 to 203) | 69.1 (62.6 to 75.7) | 66.5 (59.8 to 73.2) | 2.6 | 0.468 |
| ≥15 years | 80 | 74 | 49 | 16 | 121 (109 to 133) | 66.4 (58.0 to 74.8) | 61.4 (52.7 to 70.1) | 5.0 | |
| Sex | |||||||||
| Male | 111 | 99 | 71 | 16 | 155 (144 to 166) | 71.8 (64.7 to 78.9) | 64.0 (56.5 to 71.6) | 7.8 | 0.588 |
| Female | 101 | 103 | 66 | 20 | 158 (145 to 171) | 64.2 (56.7 to 71.7) | 65.5 (58.1 to 72.9) | −1.3 | |
| Year of report | |||||||||
| 2011–2013 | 122 | 120 | 71 | 35 | 206 (187 to 226) | 59.3 (52.6 to 66.0) | 58.3 (51.6 to 65.1) | 1.0 | <0.001 |
| 2014–2015 | 90 | 82 | 66 | 6 | 112 (106 to 118) | 80.6 (73.2 to 87.9) | 73.4 (65.2 to 81.6) | 7.2 | |
| Size of municipality | |||||||||
| <10 000 people | 27 | 28 | 22 | 2 | 35 (32 to 37) | 78.7 (65.0 to 92.4) | 81.6 (68.7 to 94.6) | −2.9 | 0.100 |
| ≥10 000 people | 177 | 148 | 110 | 23 | 238 (225 to 252) | 74.4 (68.9 to 80.0) | 62.2 (56.1 to 68.4) | 12.2 | |
| Country of birth | |||||||||
| Spain | 194 | 188 | 127 | 32 | 287 (271 to 304) | 67.6 (62.2 to 73.0) | 65.5 (60.0 to 71.0) | 2.1 | 0.696 |
| Other countries | 18 | 14 | 10 | 3 | 25 (20 to 30) | 72.3 (54.7 to 89.9) | 56.2 (36.7 to 75.7) | 16.1 | |
| Hospital beds, n | |||||||||
| <200 | 60 | 65 | 40 | 13 | 97 (87 to 108) | 61.7 (52.1 to 71.4) | 66.9 (57.5 to 76.2) | −5.1 | 0.514 |
| ≥200 | 149 | 137 | 97 | 22 | 210 (197 to 224) | 70.9 (64.7 to 77.0) | 65.2 (58.7 to 71.6) | 5.7 | |
| Clinical form | |||||||||
| Meningitis | 116 | 131 | 84 | 18 | 181 (169 to 193) | 64.2 (57.2 to 71.2) | 72.5 (66.0 to 79.0) | −8.3 | 0.936 |
| Sepsis | 82 | 66 | 50 | 10 | 108 (99 to 117) | 75.9 (67.9 to 84.0) | 61.1 (51.9 to 70.3) | 14.8 | |
| Type of reporting centre | |||||||||
| Private | 21 | 1 | 1 | 0 | 21 (21 to 21) | 100 (100 to 100) | 4.8 (−4.4 to 13.9) | 95.2 | 0.002 |
| Public | 190 | 201 | 136 | 26 | 281 (267 to 295) | 67.7 (62.2 to 73.2) | 71.6 (66.4 to 76.9) | −3.9 | |
| Serogrup | |||||||||
| B | 164 | 153 | 114 | 17 | 220 (209 to 231) | 74.6 (68.8 to 80.3) | 69.6 (63.5 to 75.6) | 5.0 | 0.636 |
| C | 26 | 21 | 16 | 3 | 34 (29 to 39) | 76.7 (62.5 to 90.9) | 61.9 (45.6 to 78.3) | 14.8 | |
MRS, microbiological reporting system; SDR, statutory disease reporting system.