Table 1.

Clinical and biochemical characteristics of the study population

Variables	Baseline	6 months	12 months	P value
Age, year	42.4±12.0
Sex
Female, n (%)	47 (61.84)
Male, n (%)	29 (38.16)
Smoking status
Non-smoker, n (%)	62 (81.58)
Smoker, n (%)	14 (18.42)
TSI, SRR (%)	446.9±185.6	346.9±181.2	302.4±173.5	<0.0001*
TBII, IU/L	11.9±11.7	6.0±8.6	4.6±6.8	<0.0001*
CAS	2.7±1.5	1.4±1.3	1.3±1.5	<0.0001*
NOSPECS score	3.9±2.2	3.4±2.3	3.4±2.4	0.0050*
Proptosis, mm	17.7±3.1	18.0±3.1	17.9±3.2	0.1523*

*P values were calculated between three visits using a linear mixed model.

CAS, clinical activity score; NOSPECS, no signs or symptoms, only signs, soft tissue involvement, proptosis, extraocular muscle involvement, corneal involvement, sight loss; SRR, specimen-to-reference ratio; TBII, thyroid-stimulating hormone receptor-binding inhibitory immunoglobulin; TSI, thyroid-stimulating immunoglobulin.