Table 4.

Clinical and biochemical characteristics: subgroup analysis of patients with active TED at baseline (n=25)

Variables	Baseline	6 months	12 months	P value
Age, years	43.6±11.84
Sex
Female, n (%)	10 (40.0)
Male, n (%)	15 (60.0)
Smoking status
Non-smoker, n (%)	17 (68.0)
Smoker, n (%)	8 (32.0)
TSI, SRR (%)	453.2±123.6	342.5±139.7	297.9±137.0	<0.0001*
TBII, IU/L	17.0±14.2	9.4±11.6	7.6±10.4	<0.0001*
CAS	4.4±0.6	1.7±1.3	1.7±1.7	<0.0001*
NOSPECS score	5.6±2.3	5.0±2.3	4.9±2.4	0.0877*
Proptosis, mm	19.2±3.5	19.7±3.4	19.6±3.9	0.3414*

*P values were calculated between three visits using a linear mixed model.

CAS, clinical activity score; NOSPECS, no signs or symptoms, only signs, soft tissue involvement, proptosis, extraocular muscle involvement, corneal involvement, sight loss; SRR, specimen-to-reference ratio; TBII, thyroid-stimulating hormone-binding inhibitory immunoglobulin; TED, thyroid eye disease; TSI, thyroid-stimulating immunoglobulin.