Table 3.

Studies evaluating the Duke Activity Status Index (DASI). n, number of patients. ∗No M-DASI thresholds reported. ^†No predictive variables reported. ^‡Median age 65 yrs; 34% of patients ASA Class ≥3. ^¶Baseline model comprised age, sex and RCRI. ^§Mean age 79 yrs, mean DASI score 30.2 (6.45 METs – calculated using original conversion formula, by Hlatky and colleagues²⁷). AUROC, area under the receiver operating characteristic curve; MET, metabolic equivalent; M-DASI, modified DASI; NPV, negative predictive value; OR, odds ratio; PPV, positive predictive value; RCRI, Revised Cardiac Risk Index.

First author, year (n)	Surgical cohort	Outcomes	Thresholds for prediction	Accuracy of prediction
Riedel, 202118 (1,455)	Elective non-cardiac surgery	Ability of a 5-item modified DASI score (M-DASI) to predict CPET-derived $\dot{V}$o2 peak and AT, compared with original (12-item) DASI	$\dot{V}$o2 peak > 16 ml kg−1 min−1, AT > 11 ml kg−1 min−1	Prediction of $\dot{V}$o2 peak > 16 ml kg−1 min−1: M-DASI: AUROC=0.73∗ Original DASI: AUROC=0.71 Prediction of AT > 11 ml kg−1 min−1: M-DASI: AUROC=0.67∗ Original DASI: AUROC=0.66
Wijeysundera, 202033 (1,546)	Elective non-cardiac surgery	30-day mortality, myocardial injury, myocardial infarction, moderate-to-severe complications	DASI score of 34	DASI < 34 associated with increased risk of 30-day mortality or myocardial infarction: OR=1.05 per 1 point decrease below 34 (95% CI, 1.00–1.09)†
Wijeysundera, 201831 (1,401) METS study	Elective non-cardiac surgery‡	30-day myocardial infarction, 30-day and 1-yr mortality	–	Correlation between $\dot{V}$o2 peak and DASI: Spearman ρ=0.43, p<0.0001† Prediction of 30-day mortality or myocardial infarction: Baseline model: AUROC 0.59¶ Baseline model + DASI: AUROC 0.67¶
Struthers, 200829 (50)	Intra-abdominal surgery§	Ability of DASI to predict CPET-derived values	$\dot{V}$o2 peak > 15 ml kg−1 min−1, AT > 11 ml kg−1 min−1	DASI > 37.45 predicted $\dot{V}$o2 peak > 15 ml kg−1 min−1: PPV 1.0 NPV 0.32 DASI > 46 predicted AT > 11 ml kg−1 min−1: PPV 1.0 NPV 0.40