Table 1.
WHO Classification of Haematolymphoid Tumours, 5th edition: B-cell lymphoid proliferations and lymphomas.
| WHO Classification, 5th edition | WHO Classification, revised 4th edition |
|---|---|
| Tumour-like lesions with B-cell predominance | |
| Reactive B-cell-rich lymphoid proliferations that can mimic lymphoma | Not previously included |
| IgG4-related disease | Not previously included |
| Unicentric Castleman disease | Not previously included |
| Idiopathic multicentric Castleman disease | Not previously included |
| KSHV/HHV8-associated multicentric Castleman disease | Multicentric Castleman disease |
| Precursor B-cell neoplasms | |
| B-cell lymphoblastic leukaemias/lymphomas | |
| B-lymphoblastic leukaemia/lymphoma, NOS | (Same) |
| B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy | B-lymphoblastic leukaemia/lymphoma with hyperdiploidy |
| B-lymphoblastic leukaemia/lymphoma with hypodiploidy | (Same) |
| B-lymphoblastic leukaemia/lymphoma with iAMP21 | (Same) |
| B-lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion | B-lymphoblastic leukaemia/lymphoma with t(9;22)(q34;q11.2); BCR-ABL1 |
| B-lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features | B-lymphoblastic leukaemia/lymphoma, BCR-ABL1-like |
| B-lymphoblastic leukaemia/lymphoma with KMT2A rearrangement | B-lymphoblastic leukaemia/lymphoma with t(v;11q23.3); KMT2A-rearranged |
| B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion | B-lymphoblastic leukaemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1 |
| B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features | Not previously included |
| B-lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion | B-lymphoblastic leukaemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1 |
| B-lymphoblastic leukaemia/lymphoma with IGH::IL3 fusion | B-lymphoblastic leukaemia/lymphoma with t(5;14)(q31.1;q32.1); IGH/IL3 |
| B-lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion | Not previously included |
| B-lymphoblastic leukaemia/lymphoma with other defined genetic abnormalities | (Same) |
| Mature B-cell neoplasms | |
| Pre-neoplastic and neoplastic small lymphocytic proliferations | |
| Monoclonal B-cell lymphocytosis | (Same) |
| Chronic lymphocytic leukaemia/small lymphocytic lymphoma | (Same) |
| (Entity deleted) | B-cell prolymphocytic leukaemia |
| Splenic B-cell lymphomas and leukaemias | |
| Hairy cell leukaemia | (Same) |
| Splenic marginal zone lymphoma | (Same) |
| Splenic diffuse red pulp small B-cell lymphoma | (Same) |
| Splenic B-cell lymphoma/leukaemia with prominent nucleoli | Not previously included (encompassing hairy cell leukaemia variant and some cases of B-cell prolymphocytic leukaemia) |
| Lymphoplasmacytic lymphoma | |
| Lymphoplasmacytic lymphoma | (Same) |
| Marginal zone lymphoma | |
| Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue | (Same) |
| Primary cutaneous marginal zone lymphoma | Not previously included (originally included under “extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue”) |
| Nodal marginal zone lymphoma | (Same) |
| Paediatric marginal zone lymphoma | (Same) |
| Follicular lymphoma | |
| In situ follicular B-cell neoplasm | In situ follicular neoplasia |
| Follicular lymphoma | (Same) |
| Paediatric-type follicular lymphoma | (Same) |
| Duodenal-type follicular lymphoma | (Same) |
| Cutaneous follicle centre lymphoma | |
| Primary cutaneous follicle centre lymphoma | (Same) |
| Mantle cell lymphoma | |
| In situ mantle cell neoplasm | In situ mantle cell neoplasia |
| Mantle cell lymphoma | (Same) |
| Leukaemic non-nodal mantle cell lymphoma | (Same) |
| Transformations of indolent B-cell lymphomas | |
| Transformations of indolent B-cell lymphomas | Not previously included |
| Large B-cell lymphomas | |
| Diffuse large B-cell lymphoma, NOS | (Same) |
| T-cell/histiocyte-rich large B-cell lymphoma | (Same) |
| Diffuse large B-cell lymphoma/ high grade B-cell lymphoma with MYC and BCL2 rearrangements | High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements |
| ALK-positive large B-cell lymphoma | (Same) |
| Large B-cell lymphoma with IRF4 rearrangement | (Same) |
| High-grade B-cell lymphoma with 11q aberrations | Burkitt-like lymphoma with 11q aberration |
| Lymphomatoid granulomatosis | (Same) |
| EBV-positive diffuse large B-cell lymphoma | EBV-positive diffuse large B-cell lymphoma, NOS |
| Diffuse large B-cell lymphoma associated with chronic inflammation | (Same) |
| Fibrin-associated large B-cell lymphoma | Not previously included (Previously considered a subtype of diffuse large B-cell lymphoma associated with chronic inflammation) |
| Fluid overload-associated large B-cell lymphoma | Not previously included |
| Plasmablastic lymphoma | (Same) |
| Primary large B-cell lymphoma of immune-privileged sites | Not previously included, encompassing primary diffuse large B-cell lymphoma of the CNS in revised 4th edition (plus primary large B-cell lymphoma of the vitreoretina and primary large B-cell lymphoma of the testis) |
| Primary cutaneous diffuse large B-cell lymphoma, leg type | (Same) |
| Intravascular large B-cell lymphoma | (Same) |
| Primary mediastinal large B-cell lymphoma | (Same) |
| Mediastinal grey zone lymphoma | B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classic Hodgkin lymphoma |
| High-grade B-cell lymphoma, NOS | (Same) |
| Burkitt lymphoma | |
| Burkitt lymphoma | (Same) |
| KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas | |
| Primary effusion lymphoma | (Same) |
| KSHV/HHV8-positive diffuse large B-cell lymphoma | HHV8-positive diffuse large B-cell lymphoma, NOS |
| KSHV/HHV8-positive germinotropic lymphoproliferative disorder | HHV8-positive germinotropic lymphoproliferative disorder |
| Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation | |
| Hyperplasias arising in immune deficiency/dysregulation | Not previously included, encompassing non-destructive post-transplant lymphoproliferative disorders, among others |
| Polymorphic lymphoproliferative disorders arising in immune deficiency/dysregulation | Not previously included, encompassing polymorphic posttransplant lymphoproliferative disorders, other iatrogenic immunodeficiency-associated lymphoproliferative disorders, among others |
| EBV-positive mucocutaneous ulcer | (Same) |
| Lymphomas arising in immune deficiency / dysregulation | Not previously included, encompassing monomorphic posttransplant lymphoproliferative disorders, classic Hodgkin lymphoma posttransplant lymphoproliferative disorders, lymphomas associated with HIV infection, among others |
| Inborn error of immunity-associated lymphoid proliferations and lymphomas | Lymphoproliferative diseases associated with primary immune disorders |
| Hodgkin lymphoma | |
| Classic Hodgkin lymphoma | (Same) |
| Nodular lymphocyte predominant Hodgkin lymphoma | (Same) |
| Plasma cell neoplasms and other diseases with paraproteins | |
| Monoclonal gammopathies | |
| Cold agglutinin disease | Not previously included |
| IgM monoclonal gammopathy of undetermined significance | (Same) |
| Non-IgM monoclonal gammopathy of undetermined significance | (Same) |
| Monoclonal gammopathy of renal significance | Not previously included |
| Diseases with monoclonal immunoglobulin deposition | |
| Immunoglobulin-related (AL) amyloidosis | Primary amyloidosis |
| Monoclonal immunoglobulin deposition disease | Light chain and heavy chain deposition disease |
| Heavy chain diseases | |
| Mu heavy chain disease | (Same) |
| Gamma heavy chain disease | (Same) |
| Alpha heavy chain disease | (Same) |
| Plasma cell neoplasms | |
| Plasmacytoma | (Same) |
| Plasma cell myeloma | (Same) |
|
Plasma cell neoplasms with associated paraneoplastic syndrome -POEMS syndrome -TEMPI syndrome -AESOP syndrome |
(Same) Except AESOP syndrome not previously included |