Table 2.
WHO Classification of Haematolymphoid Tumours, 5th edition: T-cell and NK-cell lymphoid proliferations and lymphomas.
| WHO Classification, 5th edition | WHO Classification, revised 4th edition |
| Tumour-like lesions with T-cell predominance | |
| Kikuchi-Fujimoto disease | Not previously included |
| Indolent T-lymphoblastic proliferation | Not previously included |
| Autoimmune lymphoproliferative syndrome | Not previously included |
| Precursor T-cell neoplasms | |
| T-lymphoblastic leukaemia/lymphoma | |
| T-lymphoblastic leukaemia / lymphoma, NOS | T-lymphoblastic leukaemia/lymphoma |
| Early T-precursor lymphoblastic leukaemia / lymphoma | Early T-cell precursor lymphoblastic leukaemia |
| (Entity deleted) | NK-lymphoblastic leukaemia/lymphoma |
| Mature T-cell and NK-cell neoplasms | |
| Mature T-cell and NK-cell leukaemias | |
| T-prolymphocytic leukaemia | (Same) |
| T-large granular lymphocytic leukaemia | T-cell large granular lymphocytic leukaemia |
| NK-large granular lymphocytic leukaemia | Chronic lymphoproliferative disorder of NK cells |
| Adult T-cell leukaemia/lymphoma | (Same) |
| Sezary syndrome | (Same) |
| Aggressive NK-cell leukaemia | (Same) |
| Primary cutaneous T-cell lymphomas | |
| Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder | (Same) |
| Primary cutaneous acral CD8-positive lymphoproliferative disorder | Primary cutaneous acral CD8-positive T-cell lymphoma |
| Mycosis fungoides | (Same) |
| Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis | (Same) |
| Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma | (Same) |
| Subcutaneous panniculitis-like T-cell lymphoma | (Same) |
| Primary cutaneous gamma/delta T-cell lymphoma | (Same) |
| Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma | (Same) |
| Primary cutaneous peripheral T-cell lymphoma, NOS | Not previously included |
| Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas | |
| Indolent T-cell lymphoma of the gastrointestinal tract | Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract |
| Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract | Not previously included |
| Enteropathy-associated T-cell lymphoma | (Same) |
| Monomorphic epitheliotropic intestinal T-cell lymphoma | (Same) |
| Intestinal T-cell lymphoma, NOS | (Same) |
| Hepatosplenic T-cell lymphoma | |
| Hepatosplenic T-cell lymphoma | (Same) |
| Anaplastic large cell lymphoma | |
| ALK-positive anaplastic large cell lymphoma | Anaplastic large cell lymphoma, ALK-positive |
| ALK-negative anaplastic large cell lymphoma | Anaplastic large cell lymphoma, ALK-negative |
| Breast implant-associated anaplastic large cell lymphoma | (Same) |
| Nodal T-follicular helper (TFH) cell lymphoma | |
| Nodal TFH cell lymphoma, angioimmunoblastic-type | Angioimmunoblastic T-cell lymphoma |
| Nodal TFH cell lymphoma, follicular-type | Follicular T-cell lymphoma |
| Nodal TFH cell lymphoma, NOS | Nodal peripheral T-cell lymphoma with TFH phenotype |
| Other peripheral T-cell lymphomas | |
| Peripheral T-cell lymphoma, not otherwise specified | (Same) |
| EBV-positive NK/T-cell lymphomas | |
| EBV-positive nodal T- and NK-cell lymphoma | Not previously included |
| Extranodal NK/T-cell lymphoma | Extranodal NK/T-cell lymphoma, nasal-type |
| EBV-positive T- and NK-cell lymphoid proliferations and lymphomas of childhood | |
| Severe mosquito bite allergy | (Same) |
| Hydroa vacciniforme lymphoproliferative disorder | Hydroa vacciniforme-like lymphoproliferative disorder |
| Systemic chronic active EBV disease | Chronic active EBV infection of T- and NK-cell type, systemic form |
| Systemic EBV-positive T-cell lymphoma of childhood | (Same) |