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. 2022 Jun 6;119(24):e2118048119. doi: 10.1073/pnas.2118048119

Fig. 7.

Fig. 7.

AVIL is overexpressed in other sarcomas, and its expression correlates with worse clinical outcomes. (A) cBioPortal analysis on AVIL gene. (B) Relative AVIL expression against GAPDH was measured by qRT-PCR and compared in RH30, A673, TTC-466, and TC32 (Ewing sarcoma), 402–91 (myxoid liposarcoma), JN-DSRCT (desmoplastic small round cell sarcoma), SUCCS-1 (clear cell sarcoma), A2243 (synovial sarcoma), and OsACL (osteosarcoma) cells. (C and D) GSEA analysis showed enrichment of Ewing family tumor signature (C) and EWS-FLI triggered Ewing sarcoma progenitor signature (D). (E) Clinical analysis using TCGA sarcoma dataset. A two-class model stratified by AVIL showed that the high AVIL group has a shorter overall survival. Data are presented as mean values ± SD in B, and P value was calculated by standard two-tailed t test. P values in E were calculated with two-sided Log-rank test. ***P < 0.001.