Fig. 4.

i.t. VNP20009 inhibited tumor growth of injected s.c. and subsequently implanted rechallenge intrasciatic schwannomas in syngeneic mice. (A) Schematic of the experimental design. (B) Volume of injected s.c. tumors over time by treatment (n = 6 mice/group). (C) T cell composition in injected s.c. tumors harvested at the end of the study (n = 3 mice/group). (D) Volume of rechallenge intrasciatic tumors over time by treatment (n = 6 mice/group). (E) T cell composition in rechallenge intrasciatic tumors harvested 16 d after implantation (n = 3 mice/group). SI Appendix, Fig. S11 shows the flow cytometric profiles. Repeated-measures ANOVA was utilized to compare the tumor volumes and bioluminescence between the different groups, and one-way ANOVA was used to compare the flow cytometric quantification. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01. ns, not significant.