Fig. 7.
Neutralization of pseudoviruses expressing variant S proteins. (A) Amino acid differences in S of SARS-CoV-2 variants relative to that of Wuhan are shown. Amino acids within the RBD are colored red. Abbreviations: del, deleted; ins, inserted. (B) C57BL/6 were vaccinated IM with 2 × 107 PFU of rMVA-Stri and bled 3 wk later. At the latter time, the mice were boosted and bled after 2 wk. Serum from individual mice obtained after the first (1×) and second (2×) immunizations were tested for the ability to neutralize VSV-ΔG pseudoviruses expressing the S proteins indicated in A. Points indicate individual NT50 values and bars the geometic means. Significance values compared with Wuhan are indicated by asterisks: *P < 0.03; **P < 0.002; ***P < 0.0002, ****P < 0.0001.