Fig. 5.

Stage 1 and stage 2 DAM related proteins. (A) LFQ intensities of various stage 1 and stage 2 DAM proteins in the CSF of 3- and 18-mo-old APPPS1 mice and age-matched controls (the same mice as presented in Figs. 2 and 4) based on MS data. LFQ intensities were normalized to the average LFQ value for 18-mo-old non-tg mice (log₂ scale) since APPPS1 mice were analyzed in two batches. (B) LFQ intensities of various stage 1 and 2 DAM proteins in the CSF of 3-, 11-, and 18-mo-old A30P-αS mice and age-matched non-tg mice (the same mice as presented in Figs. 3 and 4) based on MS data. Significant differences based on t tests with permutation-based FDR correction (*P < 0.05 and S0 = 0.1) are indicated for tg vs. age-matched non-tg mice and for comparisons between different age-groups of the same genotype (see also Datasets S1B and S2B).