Table 1.

 Proteins exclusively detected in aged (18-mo-old) A30P-αS

Uniprot accession	Protein name	Gene name	LFQ values in A30P-αS (18 mo)	Unique peptides (n)
P08551	Neurofilament light polypeptide	Nefl	6	27
P14873	Microtubule-associated protein 1B; MAP1B heavy chain; MAP1 light chain LC1	Map1b	6	25
Q99P91	Transmembrane glycoprotein NMB	Gpnmb	6	10
P10637	Microtubule-associated protein tau	Mapt	3	5
Q7TSJ2	Microtubule-associated protein 6	Map6	4	6
P60879	Synaptosomal-associated protein 25	Snap25	5	6
P24288	Branched-chain-amino-acid aminotransferase, cytosolic	Bcat1	4	3
Q91VR7	Microtubule-associated proteins 1A/1B light chain 3A	Map1lc3a	4	2
Q08331	Calretinin	Calb2	5	7
P15331	Peripherin	Prph	6	9
P63328/ P48453	Serine/threonine-protein phosphatase 2B catalytic subunit-α isoform/ Serine/threonine-protein phosphatase 2B catalytic subunit-β isoform	Ppp3ca/ Ppp3cb	3	6
P20357	Microtubule-associated protein 2	Map2	6	6
Q9Z121	C-C motif chemokine 8	Ccl8	5	3
Q99P72	Reticulon-4	Rtn4	4	2
P25119	Tumor necrosis factor receptor superfamily member 1B	Tnfrsf1b	5	2
O89098	Cystatin-F	Cst7	6	1
Q6S5C2	N-acetylglucosamine-1-phosphotransferase subunit gamma	Gnptg	4	4
P30275	Creatine kinase U-type, mitochondrial	Ckmt1	3	6
Q9R1Q8	Transgelin-3	Tagln3	4	2

The analysis of the A30P-αS dataset revealed a group of 19 proteins that were exclusively quantified in the oldest age group (n ≥ 3 mice; see also SI Appendix, SI Materials and Methods). The absence of LFQ signals in any of the other experimental groups, including age-matched controls, implies that these proteins were below detection limit. Hence, an increase could not be computed for these proteins. Proteins are ranked according to the average LFQ intensity in A30P-αS at 18 mo (Dataset S2A).