TABLE I.
Caspases Implicated in Alzheimer’s Disease
| Caspase | Paradigm | Measure | References |
|---|---|---|---|
| 1 | AD brain Aβ treated microglia |
mRNA Casp1 cleavage In vitro Tau cleavage |
128,143,154 |
| 2 | AD brain Aβ treated hippocampal neurons Aβ production from H4-C99 cells |
mRNA Casp2 null neurons siRNA depletion Casp2 cleavage z-VDVAD-fmk |
128,161,235 |
| 3 | AD brain Aβ production from H4-C99 cells Tg4519 mice |
mRNA z-DEVD-fmk In vitro Tau cleavage cleaved Casp3 IHC Casp3 cleavage |
128,143,235–238 |
| 4 | Aβ treatment of SK-N-SH cells | Casp4 cleavage siRNA depletion |
165,239 |
| 5 | AD brain | mRNA | 128 |
| 6 | AD brain Tg4510 mice |
mRNA In vitro Tau cleavage Casp6 cleavage |
128,131,143,236 |
| 7 | AD brain Tg4510 mice |
mRNA In vitro Tau cleavage |
128,143,236 |
| 8 | AD brain Aβ production from H4-C99 cells |
mRNA siRNA depletion z-IETD-fmk In vitro Tau cleavage cleaved Casp8 IHC |
128,134,143,235,240 |
| 9 | AD brain | mRNA cleaved Casp9 IHC |
128,240 |
| 12 | Aβ treated cortical neurons Hippocampal organotypic slices treated with Aβ |
Antisense to Casp12 Casp12 null neurons Casp12 cleavage |
162,241 |