Fig. 3.

Proteins designed for dynamic function. (a) XAA_GDVQ in the short (top, PDB 6nz1/6nxm) and long (bottom, PDB 6ny8) forms with the GDVQ hinge region (residues 73–76), Ca²⁺-coordinating residues (Asp75), and polar networks (Asn54, Asn55, Ser92 and Asn61, Asn62, Gln85) shown. (b) DANCER-2 with Trp43 in its major/exposed (PDB 5uce) and minor/buried (PDB 5ucf) state shown. (c) G_A88 (PDB 2jws) and G_B88 (PDB 2jwu) shown with Thr1 and Glu19, which interact in the G_B88 denatured state (MD simulation).