Fig. 4. Molecular chaperones preventing amyloid formation. (A) Representative structures of different classes of chaperones: Hsp70 (Escherichia coli DnaK, PDB 2KHO), Hsp90 (human Hsp90β, ref. 153), J-protein (Thermus Thermophilus DnaJ dimer, PDB 4J80), chaperonin (human TRiC/CCT complex, PDB 6NRA), small heat shock protein (sHsp; human Hsp27 oligomer, PDB 6DV5). (B) Schematic of the aggregation pathway with the action of molecular chaperones, derived from a combination of in vitro and in vivo data as described in the main text.
