Table 3. GHS Classifications Based on Occupational Toxicology Studiesb.
| Peptide Coupler | CAS No. | Dermal Sensitization GHS Categorya | Dermal Irritation/Corrosion GHS Category | Eye Irritation GHS Category |
|---|---|---|---|---|
| EDAC | 1892-57-5 | GHS category 1A | GHS category 1A | GHS category 1 |
| CDMT | 3140-73-6 | GHS category 1A | GHS category 2 | NC |
| DCC | 538-75-0 | GHS category 1A | NC | NC |
| DIC | 693-13-0 | GHS category 1A | GHS category 2 | NC |
| TDBTU | 125700-69-8 | GHS category 1A | NC | NC |
| TNTU | 125700-73-4 | GHS category 1A | NC | NC |
| TOTU | 136849-72-4 | GHS category 1A | NC | GHS category 1 |
| DPPCl | 1499-21-4 | GHS category 1A | GHS category 1B | GHS category 1 |
| CIP | 101385-69-7 | GHS category 1A | NC | NP |
| HCTU | 330645-87-9 | GHS category 1A | NC | NC |
| TCTU | 330641-16-2 | GHS category 1A | NC | NC |
| TSTU | 105832-38-0 | GHS category 1A | NC | NC |
| DMTMM | 3945-69-5 | GHS category 1A | NC | NC |
| HBTU | 94790-37-1 | GHS category 1A | NC | NC |
| PyBrOP | 132705-51-2 | GHS category 1A | NC | NP |
| TPTU | 125700-71-2 | GHS category 1A | NC | GHS category 1 |
| HATU | 148893-10-1 | GHS category 1A | NC | NC |
| TBTU | 125700-67-6 | GHS category 1A | NC | NC |
| T3P | 68957-94-8 | GHS category 1A | GHS category 1C | GHS category 1 |
| BOPCl | 68641-49-6 | GHS category 1A | NC | NP |
| COMU | 1075198-30-9 | GHS category 1B | GHS category 2 | GHS category 1 |
| TFFH | 164298-23-1 | NC (negative at ≤1%) | GHS category 2 | GHS category 1 |
| CDI | 530-62-1 | NC (negative at ≤1%) | GHS category 1C | GHS category 1 |
| TCFH | 207915-99-9 | NC (negative at ≤1%) | NC | GHS category 1 |
| PFTU | 206190-14-9 | NC (negative at ≤1%) | NC | NC |
| Peptide Coupler Hydrolysis Products | ||||
| HOBt | 123333-53-9 | NC (negative at ≤1%) | NC | NC |
| TMU | 632-22-4 | NC (negative at ≤1%) | GHS category 2 | GHS category 1 |
| NaPF6 | 21324-39-0 | NC (negative at ≤1%) | GHS category 1B | GHS category 1 |
| Oxyma | 57361-81-6 | NC (negative at ≤25%) | GHS category 1B | GHS category 1 |
| HOSu/NHS | 6066-82-6 | NC (negative at ≤1%) | GHS category 2 | GHS category 1 |
a
For skin sensitization, potent sensitizers are identified; not classified means that the compound was concluded to be negative in the LLNA based on the concentrations tested yet may be positive at a higher concentration.
b
Symbols and acronyms: NC = not classified; NP: no prediction could be made (see OECD 437).