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. 2021 Jun 22;118(7):1758–1770. doi: 10.1093/cvr/cvab210

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© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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TTS-miRs reduce apical adrenergic sensitivity and increase basal maximum adrenergic response. TTS-miR adrenaline concentration-response curves in apical/basal cardiomyocytes. (A/B) FS in apex/base. (C/D) Normalisedresponse in apex/base. (E/F) FS in apex/base with TTS-miRs together. (G/H) Normalisedresponse in apex/base with TTS-miRs together. n/N = 6/6. Mean ± SEM shown, n’ = cardiomyocytes and ‘N’ = rats, significance by non-linear regression comparing agonist vs. response for A–H (F-test, Supplementary material online, Table S1).