Table 2.
Risk of bias assessment for animal studies (SYRCLE tool) [49].
| Author | Selection bias |
Performance bias |
Detection bias |
Attrition bias |
Reporting Bias |
Other |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sequence generation | Baseline characteristics | Allocation concealment | Random housing | Blinding | Random outcome assessment | Blinding | Incomplete outcome | Selective outcome reporting | Other sources of bias | |
| Castellani et al. [50] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Erdmann et al. [51] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Bondarenko et al. [52] | Unclear risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Dziuba et al. [53] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Willbold et al. [54] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Reifenrath et al. [55] | Unclear risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Waizy et al. [56] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | High risk | Low risk | Low risk |
| Pichler et al. [19] | Unclear risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Willbold et al. [57] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Rossig et al. [58] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Tie et al. [59] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Low risk | Low risk | Low risk | Low risk |
| Diekmann et al. [60] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Angrisani et al. [61] | Unclear risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Wang et al. [62] | Unclear risk | Unclear risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Kim et al. [63] | Low risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |
| Rahmati et al. [64] | Unclear risk | Low risk | Unclear risk | Unclear risk | Unclear risk | Low risk | Unclear risk | Low risk | Low risk | Low risk |