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. Author manuscript; available in PMC: 2022 Jun 22.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Sep 16;29(23):126707. doi: 10.1016/j.bmcl.2019.126707

Table 1:

Library of novel triazole analogs synthesized from the one-pot synthesis, shown in Scheme 1 and their EC50 values

graphic file with name nihms-1544502-t0005.jpg graphic file with name nihms-1544502-t0006.jpg
R Compound Isolated yield (%) EC50 (nM) Compound Isolated yield (%) EC50 (nM)
graphic file with name nihms-1544502-t0007.jpg 3a 95 12.34±3.12 5a 92 12.31 ±2.11
graphic file with name nihms-1544502-t0008.jpg 3b 94 13.56±2.45 5b 94 10.43±2.11
graphic file with name nihms-1544502-t0009.jpg 3c 95 8.78±1.23 5c 93 11.12±3.54
graphic file with name nihms-1544502-t0010.jpg 3d 97 7.12±1.12 5d 97 8.17±2.11
graphic file with name nihms-1544502-t0011.jpg 3e 92 4.21±0.13 5e 93 3.59±1.01
graphic file with name nihms-1544502-t0012.jpg 3f 91 12.43±1.63 5f 95 13.98±2.76
graphic file with name nihms-1544502-t0013.jpg 3g 97 3.12±0.42 5g 96 3.67± 1.01