Table 1:
Patients in Interview Sample
| Characteristics | Value a |
|---|---|
| Age, mean (range), y | 55 (20–84) |
| Sex | |
| Male | 29 (61) |
| Female | 17 (39) |
| Race | |
| White | 32 (70) |
| Black | 4 (9) |
| Asian, American Indian, or Alaska Native | 3 (7) |
| Not Reported | 7 (15) |
| Ethnicity | |
| Hispanic or Latino | 4 (9) |
| Non-Hispanic/ Latino | 41 (89) |
| Not Reported | 1 (2) |
| Geographic Region | |
| West Coast (6 sites) | 15 (33) |
| Mountain West (7 sites) | 12 (26) |
| Midwest (3 sites) | 6 (13) |
| South (3 sites) | 5 (11) |
| Northeast (3 sites) | 8 (17) |
| HS degree or higher | 45 (98) |
| Enrolled in Medicare | 17 (37) |
| Primary cause of lung injury | |
| Pneumonia | 32 (70) |
| Aspiration | 7 (15) |
| Nonpulmonary Sepsis | 3 (7) |
| Other Causes | 4 (9) |
| Assessments and measurements | |
| APACHE III score, mean b | 98.00 |
| Total SOFA score, mean c | 7.59 |
| Tidal volume - ml/kg of predicted body weight, mean | 6.06 |
| FIO2, mean | 0.77 |
| Inspiratory plateau pressure -- cm of water, mean | 25.67 |
| PEEP-- cm of water, mean | 12.62 |
| Pao2:FIO2, mean | 100.14 |
| Imputed Pao2:FIO2, mean d | 76.30 |
| Treatment Status | |
| Neuromuscular Blockade | 20 (43) |
| Usual Care | 26 (57) |
| Days post-randomization, median (range) | 360 (288–484) |
| 12-month Disability Score, mean (SD) e | 3.38 (±2.4) (n=45) |
| 12-month PTSS Score, mean (SD) f | 34.5 ((±20.2) (n=44) |
| 12-month MOCA Score, mean, (SD) g | 23.5 (±4.4) (n=44) |
| 12-month Living arrangement | |
| Home independently | 17 (37) |
| Home with help | 20 (43) |
| Home with professional help | 4 (9) |
| Intermediate care, rehabilitation, or nursing facility | 2 (4) |
| Other | 3 (7) |
Data are presented as number (percentage) unless otherwise noted; percentages may sum to greater than 100% due to rounding.
The Acute Physiology and Chronic Health Evaluation (APACHE) III score consists of several parts including reason for ICU admission, age, sex, race, preexisting conditions, other factors; it ranges from 0 to 299 points with higher scores associated with greater mortality.
The Sequential Organ Failure Assessment (SOFA) score measures respiratory, cardiovascular, hepatic, coagulatory, renal, and neurologic dysfunction; it ranges from 0–24 and higher scores are associated with increased morbidity and mortality.
If an arterial blood gas was not available at randomization, the ratio was inferred from oxygen saturation as measured by pulse oximetry.
The disability score ranges from 0 to 10 and is the number of 10 activities of daily living and instrumental activities of daily living (ADL/IADL) items on which the respondent or their proxy reported difficulty due to health conditions at 12 months post-randomization; scores of 4 or greater are interpretable as representing severe disability.
The Post-Traumatic Stress Symptom (PTSS) score ranges from 0–70 and measures the frequency of 10 common symptoms of post-traumatic stress. A total score above 35 is considered suggestive of post-traumatic stress disorder.
The Montreal Cognitive Assessment (MoCA) is a 30-question test measuring validated to measure mild cognitive impairment and dementia. A score of 25 or less is considered at-risk for impairment.