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. Author manuscript; available in PMC: 2022 Jun 22.
Published in final edited form as: Nature. 2021 Aug 11;597(7874):82–86. doi: 10.1038/s41586-021-03811-w

Extended Data Fig. 9 |. Dorsal CA1 SPW-Rs more strongly correlate with glucose fluctuations than do ventral CA1 SPW-Rs.

Extended Data Fig. 9 |

a, Example histological verification of dorsal and ventral CA1 recording sites. Red triangles indicate the approximate location of the CA1 SPW-R detection channels for each region. Grey triangle indicates dorsal CA3. b, Example traces of raw LFP and bandpass-filtered LFP across both recording sites (top, ventral; bottom, dorsal). For each region, one shank with uniformly distributed recording sites along the dorsal–ventral axis is shown. c, Example LFP from channels used for ripple detection. d, Average cross-correlogram between dorsal CA1 and ventral CA1 SPW-Rs at slow timescales. Inset, average cross-correlogram between dorsal CA1 and ventral CA1 SPW-Rs at fast timescales. e, Across the three rats with simultaneous dorsal and ventral hippocampal recordings, dorsal SPW-Rs were equivalently correlated with glucose fluctuations as the previous cohorts of rats with only dorsal CA1 recordings (n = 30). Ventral SPW-Rs had a significantly (two-way t-test) weaker correlation with peripheral glucose fluctuations. f, For each rat, ventral CA1 SPW-Rs were more weakly correlated with glucose dynamics and dorsal CA1 SPW-Rs.