TABLE 3.
Performance of the AmnioQuick Duo+and PAMG-1 tests for diagnosis of prolonged PROM by duration of PROM before presentation (n=99).
| Performance evaluator | AmnioQuick Duo+ | PAMG-1 |
|---|---|---|
| Presentation with PROM ≤48 h | ||
| No. of true negatives | 10 | 10 |
| No. of true positives | 41 | 41 |
| No. of false negatives | 0 | 0 |
| No. of false positives | 0 | 0 |
| Total no. | 51 | 51 |
| Specificity, % (95% CI) | 100.0 (65.5–100.0) | 100.0 (65.5–100.0) |
| Sensitivity, % (95% CI) | 100.0 (89.3–100.0) | 100.0 (89.3–100.0) |
| NPV, % (95% CI) | 100.0 (65.5–100.0) | 100.0 (65.5–100.0) |
| PPV, % (95% CI) | 100.0 (89.3–100.0) | 100.0 (89.3–100.0) |
| Accuracy, % (95% CI)a | 100.0 (89.4–100.0) | 100.0 (89.4–100.0) |
| Presenting with PROM >48 h | ||
| No. of true negatives | 15 | 15 |
| No. of true positives | 31 | 28 |
| No. of false negatives | 2 | 5 |
| No. of false positives | 0 | 0 |
| Total no. | 48 | 48 |
| Specificity, % (95% CI) | 100.0 (74.7–100.0) | 100.0 (74.7–100.0) |
| Sensitivity, % (95% CI) | 93.9 (78.4–98.9) | 84.8 (67.3–94.3) |
| NPV, % (95% CI) | 88.2 (62.3–97.9) | 75.0 (50.6–90.4) |
| PPV, % (95% CI) | 100.0 (86.3–100.0) | 100.0 (85.0–100.0) |
| Accuracy, % (95% CI)b | 95.8 (80.5–99.2) | 89.6 (68.7–96.4) |
Abbreviations: CI, confidence interval; NPV, negative predictive value; PAMG-1, placental α-microglobulin-1; PPV, positive predictive value; PROM, premature rupture of membranes.
Among women presenting with prolonged PROM within 48 h, the AmnioQuick Duo+ accuracy of 100% was not statistically different to the accuracy of the PAMG-1 test of 100% (Pearson χ2=0.0, P=0.556; relative risk 1.00, 95% CI 0.76–1.32).
Among women presenting with PROM after more than 48 h, the AmnioQuick Duo+ accuracy of 95.8% was not statistically different to the accuracy of the PAMG-1 test of 89.6% (Pearson χ2=0.0067, P=0.4673; relative risk 1.03, 95% CI 0.78–1.37).