Condition variation of Rh-catalyzed AHF of MAA.
| |||||||
|---|---|---|---|---|---|---|---|
| Entry | Ligand | Rh/L | T (°C) | P CO/PH2 (bar) | Conversion | er of 2a (R : S) | |
| 2a | 3a | ||||||
| 1 | (S,R)-Bn-Yanphos | 1 : 3 | 100 | 5/5 | 85% | 15% | 21 : 79 |
| 2 | (S,S)-Ph-BPE | 1 : 3 | 100 | 5/5 | 76% | 24% | 52 : 48 |
| 3 | (S,S)-DTB-Bn-Yanphos | 1 : 3 | 100 | 5/5 | 53% | 47% | 66 : 34 |
| 4 | (R,R)-DTBM-Bn-Yanphos | 1 : 3 | 100 | 5/5 | 39% | 61% | 31 : 69 |
| 5 | (R,S)-DTBM-Bn-Yanphos | 1 : 3 | 100 | 5/5 | 96% | 4% | 93.5 : 6.5 |
| 6 | (R,S)-DTBM-Bn-Yanphos | 1 : 2 | 100 | 5/5 | 96% | 4% | 93 : 7 |
| 7 | (R,S)-DTBM-Bn-Yanphos | 1 : 1.5 | 100 | 5/5 | 97% | 3% | 94 : 6 |
| 8 | (R,S)-DTBM-Bn-Yanphos | 1 : 1.2 | 100 | 5/5 | 93% | 4% | 91 : 9 |
| 9 | (R,S)-DTBM-Bn-Yanphos | 1 : 1.5 | 90 | 5/5 | 89% | 3% | 96 : 4 |
| 10 | (R,S)-DTBM-Bn-Yanphos | 1 : 1.5 | 80 | 5/5 | 75% | 2% | 96 : 4 |
| 11 | (R,S)-DTBM-Bn-Yanphos | 1 : 1.5 | 90 | 10/10 | 52% | 3% | 96 : 4 |
| 12 | (R,S)-DTBM-Bn-Yanphos | 1 : 1.5 | 90 | 2.5/2.5 | 91% | 3% | 96 : 4 |