Table 1.
Demographic characteristics, oncologic histories, and treatments of 128 patients with temporal bone osteoradionecrosis (TBORN).
| Characteristic | N=128 (%) |
|---|---|
|
| |
| TBORN cases | 145 |
| Bilateral TBORN | 17 (13) |
| Sex | |
| Male | 73 (57) |
| Female | 55 (43) |
| Mean age ± SD (range), y | 62 ± 14 (24-91) |
| Race | |
| White | 89 (70) |
| Asian | 15 (12) |
| Hispanic | 10 (8) |
| Black | 7 (5) |
| Other | 7 (5) |
| Comorbidities | |
| Hypothyroidism | 45 (35) |
| Dyslipidemia | 35 (27) |
| Mandibular ORN | 18 (14) |
| Diabetes mellitus | 16 (13) |
| Maxillary ORN | 5 (4) |
| History of tobacco use | |
| Never | 74 (58) |
| Past | 34 (27) |
| Current | 20 (16) |
| Prior otologic surgeryb | 39 (27) |
| Pressure equalization tube | 21 (16) |
| Mastoidectomy | 11 (9) |
| EAC surgery | 5 (4) |
| LTBR | 3 (2) |
| Tympanoplasty | 2 (2) |
| Primary malignant site | |
| Periauricular skin | 31 (24) |
| Parotid | 28 (22) |
| Nasopharynx | 25 (20) |
| Oral cavity | 13 (10) |
| Oropharynx | 8 (6) |
| Sinonasal | 4 (3) |
| Other | 19 (15) |
| Primary pathology | |
| Squamous cell carcinoma | 40 (31) |
| Nasopharyngeal carcinoma | 22 (17) |
| Adenoid cystic carcinoma | 12 (9) |
| Sarcoma | 6 (5) |
| Basal cell carcinoma | 6 (5) |
| Melanoma | 5 (4) |
| Mucoepidermoid carcinoma | 5 (4) |
| Other | 32 (25) |
| Advanced T stage of primary malignancy | 48 (38) |
| Surgery for primary malignancy | 92 (72) |
| Mean radiation dose to primary tumor ± SD (Gray) | 61.8 ± 9.8 |
| Received 3D-CRT | 62 (48) |
| Received systemic therapy | 76 (59) |
| Recurrence of primary malignancy | 45 (35) |
| Second H&N malignancy | 24 (19) |
| H&N reirradiation | 21 (16) |
a
Unless otherwise indicated.
b
No. (%) of temporal bones (N = 145).
Abbreviations: ORN, osteoradionecrosis; EAC, external auditory canal; LTBR, lateral temporal bone resection; 3D-CRT, 3-dimensional conformal radiotherapy; H&N, head and neck.